{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:32:56Z","timestamp":1792297976795,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In February 2013, Japan became the first country in the world to cover <jats:italic>Helicobacter pylori<\/jats:italic> eradication for chronic gastritis under its National Health Insurance (NHI) system. Now that eradication therapy is covered by NHI, its usage has increased dramatically, and gastric cancer deaths have begun to decrease. We undertook a detailed epidemiological analysis to investigate effects of expanded NHI coverage for <jats:italic>H. pylori<\/jats:italic> eradication therapy on gastric cancer deaths in specific age groups. Numbers of gastric cancer deaths were determined by referencing data from Ministry of Health, Labour and Welfare reports and \u201cCancer Statistics in Japan \u2013 2018\u201d published by the Foundation for Promotion of Cancer Research. Gastric cancer deaths across all age groups have been clearly decreasing since 2013, but deaths of people aged 80\u00a0years and older are still increasing. The number of gastric cancer deaths in people aged in their 80s was 2 times higher than in people aged in their 70s and 4 times higher than in people aged in their 60s. The number of people in their 80s who had an endoscopy was less than half that of people in their 60s and 70s. The eradication therapy has increased dramatically, and gastric cancer deaths are clearly decreasing in Japan. However, this decrease in deaths has not extended to elderly adults aged in their 80s, which suggests that measures to prevent gastric cancer in people aged 80\u00a0years and older will be critical to achieving the mission of eliminating gastric cancer in Japan.<\/jats:p>","DOI":"10.1111\/cas.14586","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T07:24:30Z","timestamp":1595748270000},"page":"3845-3853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gastric cancer deaths by age group in Japan: Outlook on preventive measures for elderly adults"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7768-3434","authenticated-orcid":false,"given":"Masahiro","family":"Asaka","sequence":"first","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Kudo","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Akino","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Health Administration and Policy Tohoku University School of Medicine Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayo","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hakodate National Hospital Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.626"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Lyon, 7\u201314 June 1994","volume":"61","author":"Schistosomes, liver flukes and Helicobacter pylori","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_7_5_1","unstructured":"IARC Working Group Reports 2013 Volume 8 Helicobacter pylori Eradication as a Strategy for Preventing Gastric Cancer.http:\/\/www.iarc.fr\/en\/publications\/pdfs\u2010online\/wrk\/wrk8\/Helicobacter_pylori_Eradication.pdf"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn017"},{"key":"e_1_2_7_7_1","first-page":"138","article-title":"Evaluation of H pylori eradication by electronic recept analysis in Japan","volume":"11","author":"Fujimori K","year":"2015","journal-title":"GI Forefront"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12415"},{"key":"e_1_2_7_9_1","article-title":"Impact of health insurance coverage for Helicobacter pylori gastritis on the trends in eradication therapy in Japan: retrospective observational study and simulation study based on real\u2010 world data","volume":"7","author":"Hiroi S","year":"2017","journal-title":"BMJ"},{"key":"e_1_2_7_10_1","unstructured":"Trends in site\u2010specific crude mortality rate 1965\u20132014. Cancer Statistics in Japan\u20102018 Tokyo Japan 2018; pp 40.http:\/\/ganjoho.jp\/data\/reg_stat\/statistics\/brochure\/2018\/cancer_statistics_2018.pdf"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt163"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_2_7_13_1","unstructured":"Population dynamics survey; Vital Statistics Japan 2018 Ministry of Health Labour and Welfare."},{"key":"e_1_2_7_14_1","unstructured":"Japanese salt intake. 2015 For people fpr life for the futurehttps:\/\/www.mhlw.go.jp\/stf\/houdou\/0000041733.html"},{"key":"e_1_2_7_15_1","first-page":"4823","article-title":"High\u2010salt diet induced gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pyloti colonization in C57BL\/6 mice","volume":"59","author":"Fox JG","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21810"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90156-S"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12193"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.07.005"},{"key":"e_1_2_7_20_1","unstructured":"NDB Database (Ministry of Health Labour and Welfare website).http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000139390.html."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0897-8"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.14586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.14586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:24:38Z","timestamp":1739269478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.14586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cas.14586"],"URL":"https:\/\/doi.org\/10.1111\/cas.14586","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"2020-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}