{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:28:17Z","timestamp":1792510097596,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15K08351"],"award-info":[{"award-number":["15K08351"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K08746"],"award-info":[{"award-number":["17K08746"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucoepidermoid carcinoma (MEC) is rare, but the most common primary malignancy of the salivary gland and not infrequent in young individuals. <jats:italic>CRTC1\/3\u2010MAML2<\/jats:italic> fusions are frequently detected in MEC and are useful as a diagnostic biomarker. However, there has been debate as to whether the fusions have prognostic significance. In this study, we retrospectively collected 153 salivary gland MEC cases from 11 tertiary hospitals in Japan. As inclusion criteria, the MEC patients in this study had curative surgery as the initial treatment, received no preoperative treatment, and had no distant metastasis at the time of the initial surgery. The MEC diagnosis was validated by a central pathology review by five expert salivary gland pathologists. The <jats:italic>CRTC1\/3\u2010MAML2<\/jats:italic> fusions were detected using FISH and RT\u2010PCR. In 153 MEC cases, 90 (58.8%) were positive for <jats:italic>CRTC1\/3\u2010MAML2<\/jats:italic> fusions. During the follow\u2010up period, 28 (18.3%) patients showed tumor recurrence and 12 (7.8%) patients died. The presence of the fusions was associated with favorable tumor features. Of note, none of the fusion\u2010positive patients died during the follow\u2010up period. Statistical analysis showed that the presence of the fusions was a prognostic indicator of a better overall survival in the total and advanced\u2010stage MEC cohorts, but not in the early\u2010stage MEC cohort. In conclusion, <jats:italic>CRTC1\/3\u2010MAML2<\/jats:italic> fusions are an excellent biomarker for favorable overall survival of patients with salivary gland MEC.<\/jats:p>","DOI":"10.1111\/cas.14632","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T04:38:22Z","timestamp":1598675902000},"page":"4195-4204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Prognostic impact of <i>CRTC1\/3\u2010MAML2<\/i> fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study"],"prefix":"10.1111","volume":"111","author":[{"given":"Yoshihide","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Graduate School of Medical Sciences Nagoya City University Nagoya Japan"},{"name":"Department of Maxillofacial Surgery School of Dentistry Aichi\u2010Gakuin University Nagoya 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Otolaryngology\u2010Head and Neck Surgery Tokai University School of Medicine Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery School of Dentistry Aichi\u2010Gakuin University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hanai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Aichi Cancer Center Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kawata","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Osaka Medical College 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