{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:53:41Z","timestamp":1791640421966,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number of patients with multiple primary lung cancers (MPLC) is rising. We studied the clinical features and factors related to outcomes of MPLC patients using the database of surgically resected lung cancer (LC) cases compiled by the Japanese Joint Committee of Lung Cancer Registry. From the 18\u00a0978 registered cases, 9689 patients with clinical stage I non\u2010small\u2010cell lung cancer who achieved complete resection were extracted. Tumors were defined as synchronous MPLC when multiple LC was simultaneously resected or treatment was carried out within 2\u00a0years after the initial surgery; metachronous MPLC was defined as second LC treated more than 2\u00a0years after the initial surgery. Of these cases, 579 (6.0%) were synchronous MPLC and 477 (5.0%) metachronous MPLC, with 51 overlapping cases. Female sex, nonsmoker, low consolidation\u2010tumor ratio (CTR), and adenocarcinoma were significantly more frequent in the synchronous MPLC group, whereas patients with metachronous MPLC had higher frequencies of male sex, smoker, chronic obstructive pulmonary disease (COPD), and nonadenocarcinoma. There was no significant difference in survival rate between patients with and without synchronous or metachronous MPLC. Age, gender, CTR for second LC, and histological combination of primary and second LC were prognostic indicators for both types of MPLC. Logistic regression analysis showed that female sex, history of malignant disease other than LC, and COPD were risk factors for MPLC incidence. The present findings could have major implications regarding MPLC diagnosis and identification of independent prognostic factors, and provide valuable information for postoperative management of patients with MPLC.<\/jats:p>","DOI":"10.1111\/cas.14748","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T10:10:22Z","timestamp":1606299022000},"page":"1924-1935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Clinical features and outcomes of patients with stage I multiple primary lung cancers"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-5288","authenticated-orcid":false,"given":"Yasushi","family":"Shintani","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Okami","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Osaka International Cancer Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Department of Surgery Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-6745","authenticated-orcid":false,"given":"Shinichi","family":"Toyooka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Okayama University Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Japanese Red Cross Kumamoto Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010ichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Asamura","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Department of Surgery, School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Chida","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Dokkyo Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Jichi Medical School Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nagayasu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuo","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Mathematics Tokyo University of Science Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinoshin","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Japanese Joint Committee of Lung Cancer Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.08.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e15d8c"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00105911"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.23.1782"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00024-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.08.055"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.04.46"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S122908"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.10.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40289-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00067-U"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyx113"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.09.221"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.04.142"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23252"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000400"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2880"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.051"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.09.1964"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.01.076"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000559"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.01.024"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.02.022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16096"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201406-261OC"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00022512"},{"key":"e_1_2_8_29_1","first-page":"164","article-title":"Sublobar resection for early\u2010stage lung cancer","volume":"3","author":"Sakurai H","year":"2014","journal-title":"Transl Lung Cancer Res"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1094"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.14748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T21:41:37Z","timestamp":1693604497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.14748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,9]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/cas.14748"],"URL":"https:\/\/doi.org\/10.1111\/cas.14748","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,9]]},"assertion":[{"value":"2020-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}