{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:18Z","timestamp":1787013978267,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Globally, a decreasing incidence of male esophageal squamous cell carcinoma (ESCC) has been observed in recent decades. We evaluated the determinants of esophageal distinct iodine\u2010unstained lesions (DIULs), high\u2010cancer\u2010risk lesions and ESCC, among 3858 Japanese alcohol\u2010dependent men (40\u201079\u00a0years) who underwent chromoendoscopic screening between 2003 and 2018. The initial screening detected DIULs\u00a0\u2265\u00a05\u00a0mm in 541 patients (dysplasia in 319 and SCC in 129) and multiple DIULs in 640. The detection rates for DIULs and chronic atrophic gastritis (CAG), pack\u2010years, and the mean corpuscular volume (MCV) decreased over the course of the study period, while the detection of hiatal hernia and\/or columnar\u2010lined esophagus (HH\/CLE) and the carriers of inactive heterozygous\n                    <jats:italic>aldehyde dehydrogenase\u20102<\/jats:italic>\n                    (\n                    <jats:italic>ALDH2<\/jats:italic>\n                    , rs671) increased. Multiple logistic regression analyses showed that an older age, larger number of pack\u2010years, smaller body mass index, larger MCV, presence of a slow\u2010metabolizing\n                    <jats:italic>alcohol dehydrogenase\u20101B<\/jats:italic>\n                    genotype (rs1229984), presence of an inactive heterozygous\n                    <jats:italic>ALDH2<\/jats:italic>\n                    genotype, and more advanced degree of CAG increased the odds ratios (ORs) for DIULs, while the 2008\u20102013 and 2014\u20102018 screening periods had lower ORs for DIULs than the 2003\u20102007 screening period. The presence of HH\/CLE decreased the OR for multiple DIULs and was associated with a more proximal location of ESCC. In conclusion, the detection of DIULs in an alcohol\u2010dependent population decreased between 2003 and 2018. In addition to reported determinants of ESCC, CAG and HH\/CLE were associated with the risk of DIULs. Enigmatically, however, the decline in the detection of DIULs was not adequately explained by these factors and warrants further research.\n                  <\/jats:p>","DOI":"10.1111\/cas.14753","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T19:26:22Z","timestamp":1606677982000},"page":"734-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors for esophageal iodine\u2010unstained lesions and changing trends among Japanese alcohol\u2010dependent men (2003\u20102018)"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-1359","authenticated-orcid":false,"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Omori","sequence":"additional","affiliation":[{"name":"Endoscopy Center Kawasaki Municipal Ida Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Health Promotion National Institute of Public Health Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.433"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04377.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26296"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2737"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0435"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.256"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.116877"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214477"},{"key":"e_1_2_6_10_1","first-page":"860 e7","article-title":"Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and 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Cancer Information Service National Cancer Center Japan (Vital Statistics of Japan).https:\/\/ganjoho.jp\/reg_stat\/statistics\/dl\/index.html#mortality Accessed 16 June 2020 (in Japanese)."},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agw002"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.03.001"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28024"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24445"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.14753","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T13:32:38Z","timestamp":1692451958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.14753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/cas.14753"],"URL":"https:\/\/doi.org\/10.1111\/cas.14753","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}