{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:59:37Z","timestamp":1792699177391,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Delayed chemotherapy\u2010induced nausea and vomiting (CINV) is not well controlled in colorectal cancer (CRC) patients undergoing oxaliplatin (L\u2010OHP)\u2010based chemotherapy. Whether neurokinin\u20101 receptor antagonist addition to a first\u2010generation 5HT<jats:sub>3<\/jats:sub> antagonist (1st 5\u2010HT<jats:sub>3<\/jats:sub>RA) and dexamethasone (DEX) is beneficial to these patients remains controversial. Furthermore, whether palonosetron (PALO) or aprepitant (APR) is more effective in controlling delayed CINV is unclear. We, therefore, investigated whether PALO+DEX or 1st 5\u2010HT<jats:sub>3<\/jats:sub>RA+DEX+APR was more effective in controlling delayed CINV, and the risk factors for delayed CINV, in CRC patients undergoing L\u2010OHP\u2013based chemotherapy. Data were pooled from two prospective observational Japanese studies and a phase III trial to compare CINV incidence between the PALO\u00a0+\u00a0DEX (PALO) and 5\u2010HT<jats:sub>3<\/jats:sub>RA+DEX+APR (APR) groups by propensity score\u2013matched analysis. CINV risk factors were identified using logistic regression models. The CINV incidence was higher in the PALO group than in the APR group. Logistic regression analysis revealed alcohol consumption, motion sickness, and the PALO+DEX regimen as independent risk factors for delayed nausea, and female sex and the PALO+DEX regimen as those for delayed vomiting. Compared with prophylactic PALO\u00a0+\u00a0DEX, 1st 5\u2010HT<jats:sub>3<\/jats:sub>RA+DEX+APR was more effective in controlling delayed CINV. Thus, CRC patients receiving L\u2010OHP\u2013based chemotherapy should be treated with three antiemetics, including APR.<\/jats:p>","DOI":"10.1111\/cas.14757","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:14:17Z","timestamp":1607055257000},"page":"744-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["5HT<sub>3<\/sub>RA plus dexamethasone plus aprepitant for controlling delayed chemotherapy\u2010induced nausea and vomiting in colorectal cancer"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-4939","authenticated-orcid":false,"given":"Toshinobu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Health Care Management Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yamaguchi University Graduate School of Medicine Yamaguchi Japan"},{"name":"Cancer Biostatistics Laboratory Clinical Research Institute National Hospital Organization Kyushu Cancer Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Care Management Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan"},{"name":"Department of Pharmacy Fukuoka University Chikushi Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Iihara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gifu University Hospital Gifu City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Care Management Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Egawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Care Management Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Cancer fact sheet. 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