{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:31:58Z","timestamp":1781526718733,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angiosarcoma (AS) is a rare disease with a dismal prognosis. The treatment landscape and prognostic factors for advanced AS, including locally advanced, unresectable, and metastatic disease remain elusive. The Asian Sarcoma Consortium is an international collaborative effort to understand the sarcoma treatment landscape in Asia. We undertook a retrospective chart review of AS patients seen in 8 sarcoma academic centers across Asia. Patients with complete clinical, treatment, and follow\u2010up data were enrolled. Overall, 276 advanced AS patients were included into this study; 84 (30%) of the patients had metachronous metastatic AS. The median age was 67\u00a0y; primary sites of AS was cutaneous in 55% and visceral in 45% of patients. In total, 143 (52%) patients received at least 1 line of systemic chemotherapy. The most common first\u2010line chemotherapy regimen used was paclitaxel (47.6%) followed by liposomal doxorubicin (19.6%). The median overall survival (OS) was 7.8\u00a0mo. Significant prognostic factors for OS included age\u00a0&gt;\u00a065 (hazard ratio (HR) 1.54, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), male gender (HR 1.39, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), and a cutaneous primary AS site (HR 0.63, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). The median progression\u2010free survival (PFS) for first\u2010line chemotherapy was 3.4\u00a0mo. PFS for single vs combination or paclitaxel vs liposomal doxorubicin chemotherapy regimens were comparable. This study provides an insight into the treatment patterns and prognostic factors of advanced AS patients in Asia. Prognosis of advanced AS remains poor. Data from this study serve as a benchmark for future clinical study design.<\/jats:p>","DOI":"10.1111\/cas.14793","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T04:24:22Z","timestamp":1609734262000},"page":"1095-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The treatment landscape of advanced angiosarcoma in Asia\u2014A multi\u2010national collaboration from the Asian Sarcoma Consortium"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-4029","authenticated-orcid":false,"given":"Tom Wei\u2010Wu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pang","sequence":"additional","affiliation":[{"name":"National University Cancer Institute, Singapore National University Health System Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Puhaindran","sequence":"additional","affiliation":[{"name":"Department of Hand and Reconstructive Microsurgery National University Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myo Myint","family":"Maw","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit University of Medicine 1 Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert H.","family":"Loong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virote","family":"Sriuranpong","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine Chulalongkorn University and the King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cancer Administration and Coordination Center National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyamol","family":"Mingmalairak","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine Chulalongkorn University and the King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-9757","authenticated-orcid":false,"given":"Takeshi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-2190","authenticated-orcid":false,"given":"Makoto","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-586X","authenticated-orcid":false,"given":"Akira","family":"Kawai","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal Oncology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Farid","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Center Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Huey","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Epidemiological Sciences National Cancer Center Singapore City Singapore"},{"name":"Oncology Academic Clinical Programme Duke\u2010NUS Medical School Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Lin","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Center Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Quek","sequence":"additional","affiliation":[{"name":"Parkway Cancer Centre Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C. 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