{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:15:14Z","timestamp":1782940514050,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purposes of this study were to re\u2010confirm the usefulness of PET\/CT in the differentiation of benignity\/malignancy of neurogenic tumors in NF1 patients, and to analyze the natural course of plexiform neurofibroma (pNF) and clarify whether PET\/CT is also useful for detecting tumors other than neurogenic tumors. PET\/CT was prospectively imaged in 36 NF1 patients. There were 14 malignant peripheral nerve sheath tumors (MPNSTs) in 14 patients, and 54 pNFs in 30 patients. Nine patients had both MPNST and pNF. Maximal standardized uptake value (SUVmax) was significantly higher in MPNST (median 7.6: range 4.1\u201010.4) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) compared with that of pNF (median 3.7: range 1.6\u20109.3). The cut\u2010off value of 5.8 resulted in a sensitivity of 78.6% and specificity of 88.9%. Median age was 29\u00a0y, and median maximum tumor diameter was 82\u00a0mm in 14 MPNST patients. The 5\u2010y overall survival rate was 46.8%. Three patients with low\u2010grade MPNST were alive without disease at the time of this report. In 9 patients in which pNF and MPNST co\u2010existed, 2 showed a higher SUVmax of pNF than that of MPNST. Natural history analysis of pNF (n\u00a0=\u00a043) revealed that no factors significantly correlated with increased tumor size. Nine lesions other than neurogenic tumors were detected by PET\/CT including 5 thyroid lesions and 3 malignant neoplasms. This study revealed the usefulness and limitation of PET\/CT for NF1 patients. In the future, it will be necessary to study how to detect over time the malignant transformation of pNF to MPNST, via an intermediate tumor.<\/jats:p>","DOI":"10.1111\/cas.14802","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T05:22:55Z","timestamp":1610515375000},"page":"1114-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Limitations and benefits of FDG\u2010PET\/CT in NF1 patients with nerve sheath tumors: A cross\u2010sectional\/longitudinal study"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-6388","authenticated-orcid":false,"given":"Yoshihiro","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"},{"name":"Medical Genetics Center Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-1238","authenticated-orcid":false,"given":"Hiroshi","family":"Urakawa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0328"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"1573","article-title":"International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis","volume":"62","author":"Ferner RE","year":"2002","journal-title":"Cancer Res"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"2597","article-title":"Incidence and survival in sarcoma in the United States: a focus on musculoskeletal lesions","volume":"33","author":"Ng VY","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0846-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.3576"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20921"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1978-7"},{"issue":"56","key":"e_1_2_9_10_1","first-page":"77","article-title":"Management and prognosis of malignant peripheral nerve sheath tumors: the experience of the French Sarcoma Group (GSF\u2010GETO)","volume":"2016","author":"Valentin T","year":"1990","journal-title":"Eur J Cancer"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3910"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0523-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2724"},{"key":"e_1_2_9_14_1","article-title":"Peripheral nerve sheath tumor: differentiation of malignant from benign tumors with conventional and diffusion\u2010weighted MRI","author":"Yun JS","year":"2020","journal-title":"Eur Radiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000889"},{"key":"e_1_2_9_16_1","first-page":"6162182","article-title":"The role of [(18)F]FDG\u2010PET\/CT in predicting malignant transformation of plexiform neurofibromas in neurofibromatosis\u20101","volume":"2016","author":"Tovmassian D","year":"2016","journal-title":"Int J Surg Oncol"},{"issue":"5","key":"e_1_2_9_17_1","first-page":"575","article-title":"Conference statement. National Institutes of Health Consensus Development Conference","volume":"45","author":"Neurofibromatosis","year":"1988","journal-title":"Arch Neurol"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-1448-GOSTSR"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.05.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24755"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2060"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0030-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(03)00055-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3733-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm450"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0840-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085954"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.142372"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23736"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.7.JNS191353"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy013"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26733"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.4886"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00223-5"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488706"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4227-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa053"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy067"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.14802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:38:50Z","timestamp":1693658330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.14802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cas.14802"],"URL":"https:\/\/doi.org\/10.1111\/cas.14802","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"2020-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}