{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:56:15Z","timestamp":1751525775816,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270583"],"award-info":[{"award-number":["81270583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circular RNAs (circRNAs) have been identified to exert vital biological functions and can be used as new biomarkers in a number of tumors. However, little is known about the functions of circRNAs in myelodysplastic syndrome (MDS). Here, we aimed to investigate circRNA expression profiles and to investigate the functional and clinical value of circRNAs in MDS. Differential expression of circRNAs between MDS and control subjects was analyzed using circRNA arrays, in which we identified 145\u00a0upregulated circRNAs and 224 downregulated circRNAs. Validated by real\u2010time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. The receiver operating characteristic curve analysis of these circRNAs showed that the area under the curve was 0.7266, 0.8676, 0.7349, 0.7091, 0.8806, and 0.7472, respectively. Kaplan\u2010Meier survival analysis showed that only hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_102817 were significantly associated with overall survival. Furthermore, we generated a competing endogenous RNA network focused on hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_102817. Analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes showed that the three circRNAs were linked with some important cancer\u2010related functions and pathways.<\/jats:p>","DOI":"10.1111\/cas.14843","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T06:53:40Z","timestamp":1612940020000},"page":"1888-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-0954","authenticated-orcid":false,"given":"Wan\u2010ling","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hematology Huashan Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Huashan Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Huashan Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian\u2010yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Huashan Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Huashan Hospital of Fudan University Shanghai 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significances","volume":"8","author":"Wang X","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_11_1","unstructured":"IsaacsonPG ChottA OttG.WHO classification of tumors of haematopoietic and lymphoid tissues.2008."},{"issue":"8","key":"e_1_2_8_12_1","article-title":"Biological network exploration with Cytoscape 3","volume":"47","author":"Su G","year":"2014","journal-title":"Curr Protoc 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