{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:32:39Z","timestamp":1787563959275,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16574"],"award-info":[{"award-number":["19K16574"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral T\u2010cell lymphoma (PTCL) is a heterogeneous entity generally with a poor prognosis. Recent genomic analyses have characterized genomic alterations and described gene expression profiling and epigenetic mechanisms in PTCL, leading to reveal molecular pathophysiology in detail. One of several important findings is that heterogeneities exist in both the disease and in individuals. Among PTCL subtypes, adult T\u2010cell leukemia\/lymphoma (ATLL) and peripheral T\u2010cell lymphoma, not otherwise specified (PTCL\u2010NOS) are common in Japan. ATLL is an incurable T\u2010cell malignancy induced by human T\u2010cell lymphotropic virus type 1 (HTLV\u20101). The global genomics of ATLL can be summarized as alterations involving T\u2010cell receptor (TCR) signaling and immune escape mechanisms. This highlights the fact that ATLL is a viral\u2010mediated T\u2010cell malignancy. Interestingly, several previous studies have found that the genomics of ATLL differ according to geographical region and age at diagnosis, suggesting disease heterogeneity, though they share HTLV\u20101 infection as initial disease hit. Clonal expansion of the cells acquired by somatic mutations in ATLL\u2010related genes is identified in a part of HTLV\u20101 carriers who developed ATLL later. The risk for ATLL may be updated based on findings in detail. PTCL\u2010NOS is a heterogeneous disease type of T\u2010cell lymphoma that does not correspond to any other type of PTCL. Several studies have stratified PTCL\u2010NOS according to transcriptional, genomic, microenvironmental, and clinical aspects. These kinds of analysis from multiple aspects are useful to understand the heterogeneous group. These efforts will help guide suitable translational research to target PTCL.<\/jats:p>","DOI":"10.1111\/cas.14849","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T02:19:45Z","timestamp":1613096385000},"page":"1339-1347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comprehensive genomic analysis identifying heterogeneity in peripheral T\u2010cell lymphoma"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-0106","authenticated-orcid":false,"given":"Noriaki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation Hiroshima Japan"},{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of 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