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Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time\u2010course of mesothelioma development by MWCNT and evaluate a set of lipoprotein\u2010related molecules as potential mechanism\u2010based biomarkers for the phenomenon. Male Fischer 344 rats were injected intraperitoneally (ip) with MWCNT (MWNT\u20107) at 1\u00a0mg\/kg body weight, and necropsied at 8, 16, 24, 32, or 42\u00a0wk after injection. For biochemical analyses of the lipoprotein\u2010related molecules, more samples, including severe mesothelioma cases, were obtained from 2 other carcinogenicity tests. Histologically, in association with chronic inflammation, mesothelial proliferative lesions appeared at\n                    <jats:italic>c<\/jats:italic>\n                    . Wk\u201024. Before and at the beginning of the tumor development, a prominent infiltration of CD163\u2010positive cells was seen near mesothelial cells. The histological pattern of early mesothelioma was not a papillary structure, but was a characteristic structure with a spherical appearance, composed of the mesothelioma cells in the surface area that were underlain by connective tissue\u2010like cells. Along with the progression, mesotheliomas started to show versatile histological subtypes. Serum levels of apolipoprotein A\u2010I and A\u2010IV, and a ratio of HDL cholesterol to total cholesterol were inversely correlated with mesothelioma severity. Overall, the detailed histological sequence of mesotheliomagenesis by MWCNT is demonstrated, and indicated that the altered profile of apolipoproteins may be involved in its underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/cas.14873","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T02:01:22Z","timestamp":1614909682000},"page":"2185-2198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-5110","authenticated-orcid":false,"given":"Motoki","family":"Hojo","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Environmental Sciences Tokyo Metropolitan Institute of Public Health Tokyo 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