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In our study, 3 patients with refractory mantle cell lymphoma (MCL) and 4 patients with refractory follicular lymphoma (FL) reached stable disease (SD), partial remission (PR), or progression of disease (PD) after first\u2010time humanized anti\u2010CD19\u2010CAR T\u2010cell therapy. They received ibrutinib as a salvage treatment and kept an SD in the following 7\u201016\u00a0mo, but their disease progressed again during ibrutinib salvage treatment. All 7 patients received a second\u2010time humanized anti\u2010CD19\u2010CAR T\u2010cell therapy, which was the same as their first\u2010time anti\u2010CD19\u2010CAR T\u2010cell therapy. In total, 3 MCL patients and 3 FL patients reached complete response (CR) with the second\u2010time anti\u2010CD19\u2010CAR T\u2010cell therapy combined with ibrutinib, whereas 1 FL patient reached PR. There were no differences in the transduction efficiency and proliferation between the 2 instances of anti\u2010CD19\u2010CAR T\u2010cell therapy. However, the second\u2010time anti\u2010CD19\u2010CAR T\u2010cell therapy led to higher peaks of anti\u2010CD19\u2010CAR T cells and anti\u2010CD19\u2010CAR gene copies, but also to higher grades of cytokine release syndrome (CRS) and more serious hematological toxicity. The successful outcome of the second\u2010time anti\u2010CD19\u2010CAR T\u2010cell therapy might suggest that the previous ibrutinib treatment improved the activities of anti\u2010CD19\u2010CAR T cells.<\/jats:p>","DOI":"10.1111\/cas.14915","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T09:09:47Z","timestamp":1619860187000},"page":"2642-2651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Ibrutinib improves the efficacy of anti\u2010CD19\u2010CAR T\u2010cell therapy in patients with refractory non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"112","author":[{"given":"Meijing","family":"Liu","sequence":"first","affiliation":[{"name":"The First Central Clinical College of Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Deng","sequence":"additional","affiliation":[{"name":"The First Central 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