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Recently, <jats:italic>DLL3<\/jats:italic> has attracted interest as a novel molecular target due to its high expression in neuroendocrine carcinoma of the lung. Moreover, a DLL3\u2010targeting Ab\u2010drug conjugate, rovalpituzumab tesirine (ROVA\u2010T), has been developed as a new treatment with proven antitumor activity. However, the development of ROVA\u2010T was suspended because of shorter overall survival compared to topotecan, the second\u2010line standard treatment. Thus, several studies on the mechanism and function of <jats:italic>DLL3<\/jats:italic> in several malignancies are underway to find a new strategy for targeting <jats:italic>DLL3<\/jats:italic>. In this review, we discuss the roles of <jats:italic>DLL3<\/jats:italic> in various malignancies and the future perspectives of <jats:italic>DLL3<\/jats:italic>\u2010related research, especially as a therapeutic target.<\/jats:p>","DOI":"10.1111\/cas.15017","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T17:55:00Z","timestamp":1623261300000},"page":"2984-2992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Delta\u2010like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview"],"prefix":"10.1111","volume":"112","author":[{"given":"Kentaro","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University Takatsuki 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