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To investigate the novel therapy for triple\u2010negative breast cancer, we herein examined the effects of a new combination therapy comprising a RAF\/MEK inhibitor CH5126766, also known as VS\u20106766, which we originally discovered, and eribulin. The combination of CH5126766 and eribulin potently inhibited cell growth in the triple\u2010negative breast cancer cell lines tested. The underlying mechanism in the efficacy of this combination treatment in vitro and in vivo was due to enhanced apoptosis through the suppression of survivin and Bcl\u20102 family proteins. We also showed the suppressed expression of programmed cell death ligand 1 (PD\u2010L1) in combination therapy in vivo. We found that combination therapy with eribulin and CH5126766 for triple\u2010negative breast cancer inhibited cell growth by apoptosis and raised a possibility that immune responses through suppression of PD\u2010L1 might partially contribute to inhibition of tumor growth, indicating the potential of this combination as a novel strategy for triple\u2010negative breast cancer.<\/jats:p>","DOI":"10.1111\/cas.15071","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T14:43:22Z","timestamp":1626705802000},"page":"4166-4175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Novel RAF\/MEK inhibitor CH5126766\/VS\u20106766 has efficacy in combination with eribulin for the treatment of triple\u2010negative breast 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