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Previous studies have shown that fibroblast growth factor 13 (FGF13) is associated with resistance to platinum drugs in HeLa cells. However, the mechanism and universality of this effect have not been clarified. Here, we found that FGF13 was associated with poor platinum\u2010based chemotherapy outcomes in a variety of cancers, such as lung, endometrial, and cervical cancers, through bioinformatics analysis. We then found that FGF13 simultaneously regulates the expression and distribution of hCTR1 and ATP7A in cancer cells, causes reduced platinum influx, and promotes platinum sequestration and efflux upon cisplatin exposure. We subsequently observed that FGF13\u2010mediated platinum resistance requires the microtubule\u2010stabilizing effect of FGF13. Only overexpression of FGF13 with the \u2010SMIYRQQQ\u2010 tubulin\u2010binding domain could induce the platinum resistance effect. This phenomenon was also observed in SK\u2010MES\u20101 cells, KLE cells, and 5637 cells. Our research reveals the mechanism of FGF13\u2010induced platinum drug resistance and suggests that FGF13 can be a sensibilization target and prognostic biomarker for chemotherapy.<\/jats:p>","DOI":"10.1111\/cas.15137","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T09:35:48Z","timestamp":1631871348000},"page":"4655-4668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule\u2010stabilizing effect"],"prefix":"10.1111","volume":"112","author":[{"given":"Hang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Hebei Medical University Shijiazhuang China"},{"name":"Department of Endocrinology The Third Hospital of Hebei Medical University Shijiazhuang China"},{"name":"College of Basic Medicine Hebei Medical University Shijiazhuang 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