{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:56:34Z","timestamp":1789552594204,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Melanoma is a fatal skin malignant tumor with a poor prognosis. We found that long noncoding RNA <jats:italic>BASP1<\/jats:italic><jats:italic>\u2010AS1<\/jats:italic> is essential for the development and prognosis of melanoma. The methylation, RNA sequencing, copy number variation, mutation data, and sample follow\u2010up information of melanoma from The Cancer Genome Atlas (TCGA) were analyzed using weighted gene co\u2010expression network analysis and 366 samples common to the three omics were selected for multigroup clustering analysis. A four\u2010gene prognostic model (<jats:italic>BASP1\u2010AS1<\/jats:italic>, <jats:italic>LOC100506098<\/jats:italic>, <jats:italic>ARHGAP27P1<\/jats:italic>, and <jats:italic>LINC01532<\/jats:italic>) was constructed in the TCGA cohort and validated using the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE65904\">GSE65904<\/jats:ext-link> series. The expression of <jats:italic>BASP1\u2010AS1<\/jats:italic> was upregulated in melanoma tissues and various melanoma cell lines. Functionally, the ectopic expression of <jats:italic>BASP1\u2010AS1<\/jats:italic> promoted cell proliferation, migration, and invasion in both A375 and SK\u2010MEL\u20102 cells. Mechanically, <jats:italic>BASP1\u2010AS1<\/jats:italic> interacted with YBX1 and recruited it to the promoter of NOTCH3, initiating its transcription process. The activation of the Notch signaling then resulted in the transcription of multiple oncogenes, including c\u2010MYC, PCNA, and CDK4, which contributed to melanoma progression. Thus, <jats:italic>BASP1\u2010AS1<\/jats:italic> could act as a potential biomarker for cutaneous malignant melanoma.<\/jats:p>","DOI":"10.1111\/cas.15140","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T13:32:11Z","timestamp":1631885531000},"page":"4526-4542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["LncRNA BASP1\u2010AS1 interacts with YBX1 to regulate Notch transcription and drives the malignancy of melanoma"],"prefix":"10.1111","volume":"112","author":[{"given":"YaLing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University and National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases The First Hospital of China Medical University and Key Laboratory of Immunodermatology Ministry of Health and Ministry of Education Shenyang 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The First Hospital of China Medical University and Key Laboratory of Immunodermatology Ministry of Health and Ministry of Education Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingYi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University and National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases The First Hospital of China Medical University and Key Laboratory of Immunodermatology Ministry of Health and Ministry of Education Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University and National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases The First Hospital of China Medical University and Key Laboratory of Immunodermatology Ministry of Health and Ministry of Education Shenyang China"},{"name":"School of Dentistry Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7308-7077","authenticated-orcid":false,"given":"XiuHao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University and National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases The First Hospital of China Medical University and Key Laboratory of Immunodermatology Ministry of Health and Ministry of Education Shenyang 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