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Innate immunity plays a key role in protecting against pathogens and cancers. The stimulator of interferon genes (STING) is regarded as a key adaptor protein allowing DNA sensors recognizing exogenous cytosolic DNA to activate the type I interferon signaling cascade. In terms of EBV tumorigenicity, the role of STING remains elusive. Here we showed that treatment with the STING inhibitor, C\u2010176, suppressed EBV\u2010induced transformation in peripheral blood mononuclear cells. In an EBV\u2010LPD mouse model, C\u2010176 treatment also inhibited tumor formation and prolonged survival. Treatment with B cells alone did not affect EBV transformation, but suppression of EBV\u2010induced transformation was observed in the presence of T cells. Even without direct B cell\u2010T cell contact in a transwell system, the inhibitor reduced the transformation activity, indicating that intercellular communication by humoral factors was critical to prevent EBV\u2010induced transformation. 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