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Two\u2010hundred and ninety\u2010eight Korean women diagnosed with high\u2010grade serous and\/or endometrioid EOC from 2010 to 2015 were tested for germline and 86 specimens for somatic <jats:italic>BRCA<\/jats:italic> mutations, regardless of the family history. Clinical characteristics including survival outcomes were compared in patients with and without <jats:italic>BRCA<\/jats:italic> mutations (NCT02963688). A total of 43 different germline <jats:italic>BRCA<\/jats:italic> mutations were identified in 78 patients among 298 patients (26.2%). Somatic <jats:italic>BRCA<\/jats:italic> mutations were identified in 11 (12.8%) patients among patients without germline <jats:italic>BRCA<\/jats:italic> mutations. Haplotype analysis demonstrated no founder mutations in our Korean patient cohort. Insignificant differences in age at diagnosis, primary site, and residual disease after surgery were observed between patients with and without <jats:italic>BRCA<\/jats:italic> mutations. In multivariate analysis for overall survival (OS), the presence of <jats:italic>BRCA<\/jats:italic> mutation was significantly associated with OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.049) in addition to platinum sensitivity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), indicating it is an independent prognostic factor for survival regardless of platinum sensitivity to first\u2010line chemotherapy. In addition, a higher response rate to subsequent chemotherapy after recurrence was observed in EOC patients with <jats:italic>BRCA<\/jats:italic> mutations resulting in better OS. In the current study, the prevalence of <jats:italic>BRCA<\/jats:italic> mutations in Korean patients with EOC was higher than previously reported in other ethnic groups. We demonstrated characteristics and treatment response in Korean EOC patients with <jats:italic>BRCA<\/jats:italic> mutations. These findings may provide valuable information to be considered in future clinical trials including Asian patients.<\/jats:p>","DOI":"10.1111\/cas.15166","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T19:22:39Z","timestamp":1634671359000},"page":"5055-5067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and clinical characterization of <i>BRCA1<\/i> and <i>BRCA2<\/i> mutations in Korean patients with epithelial ovarian cancer"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-5860","authenticated-orcid":false,"given":"E Sun","family":"Paik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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