{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:54:34Z","timestamp":1790517274503,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004298","name":"Secom Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16ck0106243h0001"],"award-info":[{"award-number":["16ck0106243h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19ck0106475h0001"],"award-info":[{"award-number":["19ck0106475h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20ck0106551h0001"],"award-info":[{"award-number":["20ck0106551h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20gm1010006h0004"],"award-info":[{"award-number":["20gm1010006h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007533","name":"Kobayashi Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    containing polyketide synthase in the gut microbiota (\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    ) produce a polyketide\u2010peptide genotoxin, colibactin, and are suspected to play a role in the development of colorectal neoplasia. To clarify the role of\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    in the early stage of tumorigenesis, we investigated whether the\n                    <jats:italic>pks<\/jats:italic>\n                    status of\n                    <jats:italic>E coli<\/jats:italic>\n                    was associated with the prevalence of colorectal neoplasia. This cross\u2010sectional analysis of data from a prospective cohort in Izu Oshima, Japan included asymptomatic residents aged 40\u201079\u00a0years who underwent screening colonoscopy and provided a stool sample. We identified 543 participants with colorectal neoplasia (22 colorectal cancer and 521 adenoma) as cases and 425 participants with normal colon as controls. The\n                    <jats:italic>pks s<\/jats:italic>\n                    tatus of\n                    <jats:italic>E coli<\/jats:italic>\n                    was assayed using stool DNA and specific primers that detected\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    . The proportion of\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    was 32.6% among cases and 30.8% among controls. Compared with those with\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    , the odds ratio (OR) (95% confidence interval) for participants with\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    was 1.04 (0.77\u20101.41) after adjusting for potential confounders. No statistically significant associations were observed regardless of tumor site or number of colorectal adenoma lesions. However, stratified analyses revealed increased ORs among participants who consumed cereals over the median intake or vegetables under the median intake. Overall, we found no statistically significant association between\n                    <jats:italic>pks<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>E coli<\/jats:italic>\n                    and the prevalence of colorectal adenoma lesions among this Japanese cohort. However, positive associations were suggested under certain intake levels of cereals or vegetables.\n                  <\/jats:p>","DOI":"10.1111\/cas.15196","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T03:38:23Z","timestamp":1636947503000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of\n                    <i>Escherichia coli<\/i>\n                    containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-4131","authenticated-orcid":false,"given":"Motoki","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Division of Epidemiology Center for Public Health Sciences National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Kanehara","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Center for Public Health Sciences National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Center for Public Health Sciences National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Center for Public Health Sciences National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-7655","authenticated-orcid":false,"given":"Michihiro","family":"Mutoh","sequence":"additional","affiliation":[{"name":"Division of Prevention Center for Public Health Sciences National Cancer Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Tsunematsu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-4831","authenticated-orcid":false,"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kakugawa","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital Tokyo Japan"},{"name":"Cancer Screening Center National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ikematsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinichi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kunisawa","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"School of Food and Nutritional Sciences University of Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital Tokyo Japan"},{"name":"Cancer Screening Center National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0189-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14298"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8110489"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127059"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001261107"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.44.871"},{"key":"e_1_2_7_10_1","article-title":"Isolation of new colibactin metabolites from wild\u2010type Escherichia coli and in situ trapping of a mature colibactin derivative","author":"Zhou T","year":"2021","journal-title":"J Am Chem Soc"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7785"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224820"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056964"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-017-0185-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228217"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000319"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150064"},{"key":"e_1_2_7_19_1","unstructured":"Office for Resources PD Science and Technology Policy Bureau Ministry of Education Culture Sports Science and Technology Japan. Standard Tables of Food Composition in Japan 2015.https:\/\/www.mext.go.jp\/en\/policy\/science_technology\/policy\/title01\/detail01\/1374030.htm"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04511-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01345"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2020.066"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007203430301"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(03)00053-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah3648"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.28932"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-021-02292-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72245-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.12.035"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.21.2310"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29620"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.15196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:14:27Z","timestamp":1693095267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.15196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/cas.15196"],"URL":"https:\/\/doi.org\/10.1111\/cas.15196","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"2021-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}