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However, patients with malignant meningioma typically experience recurrence, undergo multiple surgical resections, and ultimately have a poor prognosis. Thus far, effective chemotherapy for malignant meningiomas has not been established. We recently reported the efficacy of eribulin (Halaven) for glioblastoma with a telomerase reverse transcriptase (TERT) promoter mutation. This study investigated the anti\u2013tumor effect of eribulin against TERT promoter mutation\u2010harboring human malignant meningioma cell lines in vitro and in vivo. Two meningioma cell lines, IOMM\u2010Lee and HKBMM, were used in this study. The strong inhibition of cell proliferation by eribulin via cell cycle arrest was demonstrated through viability assay and flow cytometry. Apoptotic cell death in malignant meningioma cell lines was determined through vital dye assay and immunoblotting. Moreover, a wound healing assay revealed the suppression of tumor cell migration after eribulin exposure. Intraperitoneal administration of eribulin significantly prolonged the survival of orthotopic xenograft mouse models of both malignant meningioma cell lines implanted in the subdural space (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Immunohistochemistry confirmed apoptosis in brain tumor tissue treated with eribulin. Overall, these results suggest that eribulin is a potential therapeutic agent for malignant meningiomas.<\/jats:p>","DOI":"10.1111\/cas.15221","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T06:35:08Z","timestamp":1638081308000},"page":"697-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-1714","authenticated-orcid":false,"given":"Tomoyuki","family":"Nakano","sequence":"first","affiliation":[{"name":"Division of Brain Tumor Translational Research National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"},{"name":"Department of Neurosurgery Tokyo Medical and Dental University Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Brain Disease Translational Research Juntendo University 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