{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:25Z","timestamp":1790775445480,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may involve dysbiosis of the gut microbiota and the accompanying chronic inflammation or altered metabolism. In this study, we evaluated the possible effects of modifying the gut microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer\u2010related muscle wasting and its mechanism using a colon\u201026\u00a0murine cachexia model. Compared with a fiber\u2010free (FF) diet, PHGG contained fiber\u2010rich (FR) diet\u2013attenuated skeletal muscle loss in cachectic mice by suppressing the elevation of the major muscle\u2010specific ubiquitin ligases Atrogin\u20101 and MuRF1, as well as the autophagy markers LC3 and Bnip3. Although tight\u2010junction markers were partially reduced in both FR and FF diet\u2013fed cachectic mice, the abundance of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    , and unclassified\n                    <jats:italic>S24<\/jats:italic>\n                    \u2010\n                    <jats:italic>7 family<\/jats:italic>\n                    increased by FR diet, contributing to the retention of the colonic mucus layer. The reinforcement of the gut barrier function resulted in the controlled entry of pathogens into the host system and reduced circulating levels of lipopolysaccharide\u2010binding protein (LBP) and IL\u20106, which in turn led to the suppression of proteolysis by downregulating the ubiquitin\u2010proteasome system and autophagy pathway. These results suggest that dietary fiber may have the potential to alleviate skeletal muscle loss in cancer cachexia, providing new insights for developing effective strategies in the future.\n                  <\/jats:p>","DOI":"10.1111\/cas.15306","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T10:00:28Z","timestamp":1645696828000},"page":"1789-1800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Water\u2010soluble dietary fiber alleviates cancer\u2010induced muscle wasting through changes in gut microenvironment in mice"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-7923","authenticated-orcid":false,"given":"Tomoki","family":"Sakakida","sequence":"first","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-9710","authenticated-orcid":false,"given":"Takeshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-1744","authenticated-orcid":false,"given":"Yuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Human Immunology and Nutrition Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Human Immunology and Nutrition Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Higashimura","sequence":"additional","affiliation":[{"name":"Department of Food Science Ishikawa Prefectural University  Nonoichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Okayama","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Abe","sequence":"additional","affiliation":[{"name":"Nutrition Division Taiyo Kagaku Co. 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