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Cell adhesion molecule 1 (CADM1) is overexpressed in adult T\u2010cell leukemia\/lymphoma (ATL) and provides a cell\u2010surface diagnostic marker. CADM1 promotes the adhesion of ATL cells to vascular endothelial cells and multiple organ infiltration in mice. However, its binding partner on host cells has not yet been identified. In this study, we show that CADM1 promotes transendothelial migration of ATL cells in addition to the adhesion to vascular endothelial cells. Moreover, CADM1 enhances liver infiltration of mouse T\u2010cell lymphoma cells, EL4, after tail vein injection, whereas a CADM1\u00a0mutant lacking adhesive activity did not. Among the known CADM1\u2010binding proteins expressed in primary endothelial cells, only CADM1 and CADM4 could induce morphological extension of ATL cells when plated onto glass coated with these proteins. Furthermore, CADM1\u2010mediated liver infiltration of EL4 cells was canceled in conventional and vascular endothelium\u2010specific <jats:italic>Cadm1<\/jats:italic>\u00a0knockout mice, whereas it was not canceled in <jats:italic>Cadm4<\/jats:italic>\u00a0knockout mice. These results suggest that CADM1 on host vascular endothelial cells is required for organ infiltration of ATL and other T\u2010cell lymphomas expressing CADM1.<\/jats:p>","DOI":"10.1111\/cas.15307","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T16:15:24Z","timestamp":1645719324000},"page":"1669-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Trans<\/i>\u2010homophilic interaction of CADM1 promotes organ infiltration of T\u2010cell lymphoma by adhesion to vascular endothelium"],"prefix":"10.1111","volume":"113","author":[{"given":"Yutaka","family":"Kasai","sequence":"first","affiliation":[{"name":"Division of Molecular Pathology The Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Pey","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology 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