{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:54:00Z","timestamp":1776869640924,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003662","name":"Korea Evaluation Institute of Industrial Technology","doi-asserted-by":"publisher","award":["10078393"],"award-info":[{"award-number":["10078393"]}],"id":[{"id":"10.13039\/501100003662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the anticancer effect of the aptamer\u2010conjugated gemcitabine\u2010loaded atelocollagen patch in a pancreatic cancer patient\u2013derived xenograft (PDX) model to propose a future potential adjuvant surgical strategy during curative pancreatic resection for pancreatic cancer. A pancreatic cancer PDX model was established. Animals were grouped randomly into a no\u2010treatment control group; treatment group treated with intraperitoneal gemcitabine injection (IP\u2010GEM) or aptamer\u2010conjugated gemcitabine (APT:GEM); and transplant with three kinds of patches: atelocollagen\u2010aptamer\u2010gemcitabine (patch I), atelocollagen\u2010inactive aptamer\u2010gemcitabine (patch II), and atelocollagen\u2010gemcitabine (patch III). Tumor volumes and response were evaluated based on histological analysis by H&amp;E staining and Immunohistochemistry (IHC) was performed. Anticancer therapy\u2013related toxicity was evaluated by hematologic findings. The patch I group showed the most significant reduction of tumor growth rate, compared with the no\u2010treatment group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, other treatment groups were not found to show significant reduction in tumor growth rate (0.05\u00a0&lt;\u00a0<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.1). There was no microscopic evidence suggesting potential toxicity, such as inflammation, nor necrotic changes in liver, lung, kidney, and spleen tissue. In addition, no leukopenia, anemia, or neutropenia was observed in the patch I group. This implantable aptamer\u2010drug conjugate system is thought to be a new surgical strategy to augment the oncologic significance of margin\u2010negative resection in treating pancreatic cancer in near future.<\/jats:p>","DOI":"10.1111\/cas.15318","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T09:10:36Z","timestamp":1646385036000},"page":"1752-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anticancer effect of locally applicable aptamer\u2010conjugated gemcitabine\u2010loaded atelocollagen patch in pancreatic cancer patient\u2013derived xenograft models"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-8437","authenticated-orcid":false,"given":"Seung Soo","family":"Hong","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery Department of Surgery Yonsei University College of Medicine  Seoul 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-4658","authenticated-orcid":false,"given":"Chang Moo","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center Severance Hospital  Seoul 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