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However, instability of nanoparticles in body fluids causes inefficient retention, reducing its anticancer effects. We have previously developed anticancer nanoparticles containing tocopheryl succinate, which showed high <jats:italic>in vivo<\/jats:italic> stability and multifunctional anticancer effects. In the present study, we have demonstrated that peritoneal dissemination derived from colon cancer was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. The biodistribution of tocopheryl succinate nanoparticles was evaluated using inductively coupled plasma mass spectroscopy and imaging analysis in mice administered quantum dot encapsulated tocopheryl succinate nanoparticles. Intraperitoneal administration of tocopheryl succinate nanoparticles showed longer retention in the abdominal cavity than by its intravenous (i.v.) administration. Moreover, due to effective biodistribution, tumor growth was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. Furthermore, the anticancer effect was attributed to the inhibition of cancer cell proliferation and improvement of the intraperitoneal microenvironment, such as decrease in the levels of vascular endothelial growth factor A, interleukin 10, and M2\u2010like phenotype of tumor\u2010associated macrophages. Collectively, intraperitoneal administration of tocopheryl succinate nanoparticles is expected to have multifaceted antitumor effects against colon cancer with peritoneal dissemination.<\/jats:p>","DOI":"10.1111\/cas.15321","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T06:51:40Z","timestamp":1646635900000},"page":"1779-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intraperitoneal administration of nanoparticles containing tocopheryl succinate prevents peritoneal dissemination"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-6168","authenticated-orcid":false,"given":"Susumu","family":"Hama","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Research Institute of Pharmaceutical Sciences Musashino University  Tokyo 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