{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:33:43Z","timestamp":1787924023899,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical significance of intraductal carcinoma of the prostate (IDC\u2010P) in men with nonmetastatic prostate cancer (PCa) treated with high\u2010dose external\u2010beam radiation therapy remains unclear. The aim of this study was to evaluate the impact of IDC\u2010P in men who received intensity\u2010modulated radiation therapy (IMRT) for nonmetastatic PCa. All patients with high\u2010risk (H\u2010R) and very high\u2013risk (VH\u2010R) PCa who received IMRT between September 2000 and December 2013 at our institution were analyzed retrospectively. We re\u2010reviewed biopsy cores for the presence of IDC\u2010P. Treatment consisted of IMRT (median: 78\u2009Gy at 2\u2009Gy per fraction) plus 6\u2010month neoadjuvant hormonal therapy (HT). In total, 154 consecutive patients with H\u2010R and VH\u2010R PCa were analyzed. Intraductal carcinoma of the prostate was present in 27.9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a043). The median follow\u2010up period was 8.4\u2009years. The 10\u2010year PCa\u2010specific survival, biochemical failure (BF), clinical failure, and castration\u2010resistant PCa rates were 90.0%, 47.8%, 27.5%, and 24.5% in patients with IDC\u2010P, and 96.6%, 32.6%, 10.8%, and 7.0% in those without IDC\u2010P, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.12, 0.04, 0.0031, and 0.012, respectively). In multivariable analysis, IDC\u2010P was not identified as an independent predictive factor for BF (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.26). The presence of IDC\u2010P was correlated with a significantly higher incidence of disease progression in men with H\u2010R and VH\u2010R PCa who received IMRT, although it was not identified as an independent predictive factor for BF. Further investigations are needed to determine the significance of IDC\u2010P as an independent predictive factor for survival outcomes.<\/jats:p>","DOI":"10.1111\/cas.15392","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T07:19:20Z","timestamp":1651821560000},"page":"2425-2433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical significance of <scp>IDC\u2010P<\/scp> as predictive factor after intensity\u2010modulated radiation therapy"],"prefix":"10.1111","volume":"113","author":[{"given":"Rihito","family":"Aizawa","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-4366","authenticated-orcid":false,"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital, 1\u20101 Yazakokarimata  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-2816","authenticated-orcid":false,"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Division of Urology Otsu Redcross Hospital  Otsu\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-8746","authenticated-orcid":false,"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_2_8_3_1","unstructured":"EAU Guidelines. 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