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We previously developed a cell\u2010based anti\u2010cancer vaccine platform involving artificial adjuvant vector cells (aAVCs) capable of inducing a strong adaptive response by enhancing the innate immunity. aAVCs are target antigen\u2010transfected allogenic cells that simultaneously express the natural killer T\u2010cell ligand\u2013CD1d complex on their surface. In the present study, we applied this system for targeting the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) spike protein (CoV\u20102\u2010S) using CoV\u20102\u2010S\u2010expressing aAVCs (aAVC\u2010CoV\u20102) and evaluated the immune response in a murine model. A single dose of aAVC\u2010CoV\u20102 induced a large amount of CoV\u20102\u2010S\u2010specific, multifunctional CTLs in addition to CD4<jats:sup>+<\/jats:sup> T\u2010cell\u2010dependent anti\u2010CoV\u20102\u2010S\u2010specific Abs. CoV\u20102\u2010S\u2010specific CTLs infiltrated the lung parenchyma and persisted as long\u2010term memory T cells. Furthermore, we immunized mice with CoV\u20102\u2010S\u2010 and tumor\u2010associated antigen (TAA)\u2010co\u2010expressing aAVCs (aAVC\u2010TAA\/CoV\u20102) and evaluated whether the anti\u2010SARS\u2010CoV\u20102 and antitumor CTLs were elicited. We found that the aAVC\u2010TAA\/CoV\u20102\u2010S therapy exerted apparent antitumor effects and induced CoV\u20102\u2010S\u2010specific CTLs. These findings suggest aAVC\u2010TAA\/CoV\u20102\u2010S therapy as a promising vaccine candidate for preventing COVID\u201019, as well as enhancing the effectiveness of cancer therapies.<\/jats:p>","DOI":"10.1111\/cas.15434","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T11:35:38Z","timestamp":1653219338000},"page":"2536-2547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A single immunization with cellular vaccine confers dual protection against <scp>SARS\u2010CoV<\/scp>\u20102 and cancer"],"prefix":"10.1111","volume":"113","author":[{"given":"Kanako","family":"Shimizu","sequence":"first","affiliation":[{"name":"Laboratory for Immunotherapy RIKEN Center for Integrative Medical Science  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Laboratory for Immunotherapy 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