{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:20Z","timestamp":1787013980260,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to validate the Proactive Molecular Risk Classifier for Endometrial Cancer, a modified version of The Cancer Genome Atlas, using data from 184 patients with endometrial cancer (median age: 57.5\u2009years; median follow\u2010up period: 109\u2009months) who had undergone radical surgery (including systemic lymphadenectomy) and subsequent adjuvant chemotherapy (patients with intermediate or high recurrence risk) from 2003 to 2015. Tissue microarrays were prepared from surgical specimens and classified using the conventional clinical risk classifier. Immunohistochemistry was used to detect mismatch repair proteins, L1 cell adhesion molecule, and p53. Direct sequencing was used to identify hotspot mutations in the polymerase\u2010epsilon gene. Forty\u2010five patients were identified as having high L1 cell adhesion molecule expression, 41 as low risk, 34 as mismatch repair\u2010deficient, 13 as polymerase\u2010epsilon gene\u2010mutated, five as having abnormal p53, and 46 as other. Patients were stratified into significantly different prognostic groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001): favorable (low risk and polymerase\u2010epsilon gene\u2010mutated), intermediate (mismatch repair\u2010deficient and other), and unfavorable (high L1 cell adhesion molecule expression and abnormal p53) with 5\u2010year disease\u2010specific survival rates of 100%, 93.8%, and 75.1%, respectively (Kaplan\u2013Meier method). The combination of conventional recurrent risk classification, sequencing for polymerase\u2010epsilon gene mutations and immunohistochemistry for L1 cell adhesion molecule, p53, and mismatch repair proteins can be used to determine the prognoses of patients with endometrial cancer.\n                  <\/jats:p>","DOI":"10.1111\/cas.15460","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T02:35:08Z","timestamp":1655346908000},"page":"3134-3147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The prognosis of endometrial cancers stratified with conventional risk factors and modified molecular classification"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-9607","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine and Faculty of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine and Faculty of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako C.","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Center for Development of Advanced Diagnostics Institute of Health Science Innovation for Medical Care Hokkaido University Hospital  Sapporo Japan"},{"name":"Research Division of Genome Companion Diagnostics Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology International University of Health and Welfare Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine and Faculty of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Center for Development of Advanced Diagnostics Institute of Health Science Innovation for Medical Care Hokkaido University Hospital  Sapporo Japan"},{"name":"Research Division of Genome Companion Diagnostics Hokkaido University Hospital  Sapporo 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