{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:18Z","timestamp":1791925698068,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer cachexia is a multifactorial disease that causes continuous skeletal muscle wasting. Thereby, it seems to be a key determinant of cancer\u2010related death. Although anamorelin, a ghrelin receptor agonist, has been approved in Japan for the treatment of cachexia, few medical treatments for cancer cachexia are currently available. Myostatin (MSTN)\/growth differentiation factor 8, which belongs to the transforming growth factor\u2010\u03b2 family, is a negative regulator of skeletal muscle mass, and inhibition of MSTN signaling is expected to be a therapeutic target for muscle\u2010wasting diseases. Indeed, we have reported that peptide\u20102, an MSTN\u2010inhibiting peptide from the MSTN prodomain, alleviates muscle wasting due to cancer cachexia. Herein, we evaluated the therapeutic benefit of myostatin inhibitory D\u2010peptide\u201035 (MID\u201035), whose stability and activity were more improved than those of peptide\u20102 in cancer cachexia model mice. The biologic effects of MID\u201035 were better than those of peptide\u20102. Intramuscular administration of MID\u201035 effectively alleviated skeletal muscle atrophy in cachexia model mice, and the combination therapy of MID\u201035 with anamorelin increased food intake and maximized grip strength, resulting in longer survival. Our results suggest that this combination might be a novel therapeutic tool to suppress muscle wasting in cancer cachexia.<\/jats:p>","DOI":"10.1111\/cas.15491","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:48:22Z","timestamp":1658141302000},"page":"3547-3557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Combination therapy with anamorelin and a myostatin inhibitor is advantageous for cancer cachexia in a mouse model"],"prefix":"10.1111","volume":"113","author":[{"given":"Kako","family":"Hanada","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell Regulation Tokyo University of Pharmacy and Life Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpei","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Regulation Tokyo University of Pharmacy and Life Sciences  Tokyo 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