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Despite recent progress in the management strategy, peritoneal dissemination remains a determinant of poor ovarian cancer prognosis. Using various histological types of patient\u2010derived ovarian cancer organoids, the roles of the apicobasal polarity of ovarian cancer cell clusters in peritoneal dissemination were studied. First, it was found that both ovarian cancer tissues and ovarian organoids showed apicobasal polarity, where zonula occludens\u20101 (ZO\u20101) and integrin beta 4 (ITGB4) served as markers for apical and basal sides, respectively. The organoids in suspension culture, as a model of cancer cell cluster floating in ascites, showed apical\u2010out\/basal\u2010in polarity status, while once embedded in extracellular matrix (ECM), the organoids switched their polarity to apical\u2010in\/basal\u2010out. This polarity switch was accompanied by the SRC kinase family (SFK) phosphorylation and was inhibited by SFK inhibitors. SFK inhibitors abrogated the adherence of the organoids onto the ECM\u2010coated plastic surface. When the organoids were seeded on a mesothelial cell layer, they cleared and invaded mesothelial cells. In vivo, dasatinib, an SFK inhibitor, suppressed peritoneal dissemination of ovarian cancer organoids in immunodeficient mice. These results suggest SFK\u2010mediated polarity switching is involved in peritoneal metastasis. Polarity switching would be a potential therapeutic target for suppressing peritoneal dissemination in ovarian cancer.<\/jats:p>","DOI":"10.1111\/cas.15493","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T09:30:12Z","timestamp":1658136612000},"page":"3437-3448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Polarity switching of ovarian cancer cell clusters via\n                    <scp>SRC<\/scp>\n                    family kinase is involved in the peritoneal dissemination"],"prefix":"10.1111","volume":"113","author":[{"given":"Mayuko","family":"Kawata","sequence":"first","affiliation":[{"name":"Department of Clinical Bioresource Research and Development Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Obstetrics and Gynecology Osaka University Graduate School of Medicine  Osaka 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