{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:57:35Z","timestamp":1789124255440,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG350071"],"award-info":[{"award-number":["CMRPG350071"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["XMRPG1A0081"],"award-info":[{"award-number":["XMRPG1A0081"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW109\u2010TDU\u2010B\u2010212\u2010134011"],"award-info":[{"award-number":["MOHW109\u2010TDU\u2010B\u2010212\u2010134011"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST108\u20102314\u2010B\u2010182\u2010006"],"award-info":[{"award-number":["MOST108\u20102314\u2010B\u2010182\u2010006"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have compared the molecular responses between e14a2 and e13a2 <jats:italic>BCR::ABL1<\/jats:italic> transcripts in chronic myeloid leukemia (CML) patients treated with front\u2010line imatinib, but there were very limited studies on nilotinib or dasatinib\u2010treated patients. We retrospectively analyzed the molecular responses in 1124 CML patients with the e14a2 or e13a2 transcript receiving front\u2010line imatinib, nilotinib or dasatinib treatment. Patients with the e14a2 transcript had higher optimal response rates than those with the e13a2 transcript at 12\u2009months in the imatinib\u2010treated group, and 6 and 12\u2009months in the nilotinib\u2010treated group. The optimal response rates were not significantly different between the two transcripts in the dasatinib\u2010treated group at landmark molecular responses. With a median follow\u2010up time of 48.4\u00a0months, higher cumulative incidences of <jats:italic>BCR::ABL1<\/jats:italic> International Scale \u22641% and major molecular response were observed in patients with the e14a2 rather than the e13a2 transcript receiving front\u2010line imatinib or nilotinib treatment, but not in dasatinib\u2010treated patients. The progression\u2010free survival and overall survival did not differ between the two transcripts in all three treatment groups. In view of the speed and depth of molecular responses, <jats:italic>BCR::ABL1<\/jats:italic> transcript subtypes might provide helpful information in selecting a front\u2010line tyrosine kinase inhibitor for individual young patients with future potential treatment\u2010free remission.<\/jats:p>","DOI":"10.1111\/cas.15501","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:54:49Z","timestamp":1658566489000},"page":"3518-3527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of molecular responses and outcomes between <i>BCR::ABL1<\/i> e14a2 and e13a2 transcripts in chronic myeloid leukemia"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-1166","authenticated-orcid":false,"given":"Yi\u2010Jiun","family":"Su","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Linkou 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Hospital  Taichung Taiwan"},{"name":"Internal Medicine College of Medicine, China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chun","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Kaohsiung  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Liang","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh\u2010Lin Jerry","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Life Science Tunghai University  Taichung Taiwan"},{"name":"School of Medicine, Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Ching","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung University, School of Medicine  Taoyuan Taiwan"},{"name":"Division of Hematology\u2010Oncology Chang Gung Memorial Hospital at Chiayi  Chiayi 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