{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:16:26Z","timestamp":1778044586640,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Breast cancer gene 1<\/jats:italic> (<jats:italic>BRCA1<\/jats:italic>) plays roles in DNA repair and centrosome regulation and is involved in DNA damage\u2010induced centrosome amplification (DDICA). Here, the centrosomal localization of BRCA1 and the kinases involved in centrosome duplication were analyzed in each cell cycle phase after treatment with DNA crosslinker cisplatin (CDDP). CDDP treatment increased the centrosomal localization of BRCA1 in early S\u2013G2 phase. BRCA1 contributed to the increased centrosomal localization of Aurora A in S phase and that of phosphorylated Polo\u2010like kinase 1 (PLK1) in late S phase after CDDP treatment, resulting in centriole disengagement and overduplication. The increased centrosomal localization of BRCA1 and Aurora A induced by CDDP treatment involved the nuclear export of BRCA1 and BRCA1 phosphorylation by ataxia telangiectasia mutated (ATM). Patient\u2010derived variants and mutations at phosphorylated residues of BRCA1 suppressed the interaction between BRCA1 and Aurora A, as well as the CDDP\u2010induced increase in the centrosomal localization of BRCA1 and Aurora A. These results suggest that CDDP induces the phosphorylation of BRCA1 by ATM in the nucleus and its transport to the cytoplasm, thereby promoting the centrosomal localization Aurora A, which phosphorylates PLK1. The function of BRCA1 in the translocation of the DNA damage signal from the nucleus to the centrosome to induce centrosome amplification after CDDP treatment might support its role as a tumor suppressor.<\/jats:p>","DOI":"10.1111\/cas.15573","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T18:29:55Z","timestamp":1662748195000},"page":"4230-4243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>BRCA1<\/scp> transports the <scp>DNA<\/scp> damage signal for <scp>CDDP<\/scp>\u2010induced centrosome amplification through the centrosomal Aurora A"],"prefix":"10.1111","volume":"113","author":[{"given":"Huicheng","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Cancer Biology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-3467","authenticated-orcid":false,"given":"Yuki","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Cancer Biology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhou","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Cancer Biology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazune","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takato","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ideta","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Tohoku University School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Ui","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shino","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Cancer Biology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Shindo","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Oncology Miyagi Cancer Center Research Institute  Natori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Gonda","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3023-1227","authenticated-orcid":false,"given":"Chikashi","family":"Ishioka","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Medical Research Institute Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuro","family":"Iwabuchi","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience and Biotechnology Tokyo University of Technology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-1290","authenticated-orcid":false,"given":"Natsuko","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology; Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Cancer Biology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Laboratory of Cancer Biology, Graduate School of Life Sciences Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0218-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080842"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14859"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.169730"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.5.2845"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0192"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.127"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2015.1075643"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.19.8656-8668.2005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.19.8457-8466.2004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209028"},{"key":"e_1_2_9_16_1","first-page":"7713","article-title":"Identification of a gamma\u2010tubulin\u2010binding domain in BRCA1","volume":"61","author":"Hsu LC","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.10.028"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0647-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.238931"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.151753"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.07.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9077"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aar4195"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10577-015-9503-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10577-015-9505-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.964973"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.12.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132269599"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.20477"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.12.15648"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.05.050"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.106096"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20135801"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24579"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.08.023"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10-03-0246"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.2.271"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3659"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014027"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2994"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525129113"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-017-1076-1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.4.837"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04985"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.327296"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22251"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.09039"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0464"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2578"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01124-08"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0010-5"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.2.708-718.2004"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.21396"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-21-0064"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.310"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08136"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.3.3834"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.271"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.15573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:19:21Z","timestamp":1692566361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.15573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/cas.15573"],"URL":"https:\/\/doi.org\/10.1111\/cas.15573","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]},"assertion":[{"value":"2022-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}