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Cells with these genetic alterations acquire a leukemia\u2010initiating ability and show unique expression profiles. The distribution of B\u2010ALL molecular subtypes is greatly dependent on age, which also affects treatment responsiveness and long\u2010term survival, partly accounting for the inferior outcome in adolescents and young adults (AYA) and (older) adults with B\u2010ALL. Recent advances in sequencing technology, especially RNA sequencing and the application of these technologies in large B\u2010ALL cohorts have uncovered B\u2010ALL molecular subtypes prevalent in AYA and adults. These new insights supply more precise estimations of prognoses and targeted therapies informed by sequencing results, as well as a deeper understanding of the genetic basis of AYA\/adult B\u2010ALL. This article provides an account of these technological advances and an overview of the recent major findings of B\u2010ALL molecular subtypes in adults.<\/jats:p>","DOI":"10.1111\/cas.15583","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T06:49:25Z","timestamp":1663224565000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oncogenic lesions and molecular subtypes in adults with B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-0976","authenticated-orcid":false,"given":"Takahiko","family":"Yasuda","sequence":"first","affiliation":[{"name":"Clinical Research Center National Hospital Organization Nagoya Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Sanada","sequence":"additional","affiliation":[{"name":"Clinical 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