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CXCL10 has been reported to play an important role in antitumor immunity as a chemotactic factor. Tumor development is always accompanied by the formation of an immunosuppressive tumor microenvironment, and the role of CXCL10 in tumor immunosuppression remains unclear. Here, we reported that CXCL10 expression was significantly upregulated in mice with melanoma, and tumor cells secreted large amounts of CXCL10. Myeloid\u2010derived suppressor cells (MDSCs) are an important part of the immunosuppressive tumor microenvironment. Our results showed that CXCL10 promoted the proliferation of monocyte\u2010like (mo)\u2010MDSCs by activating the p38 MAPK signaling pathway through CXCR3, which led to the abnormal accumulation of mo\u2010MDSCs under tumor conditions. This finding provides a new understanding of the mechanism by which a tumor\u2010induced immunosuppressive microenvironment forms and suggests that CXCL10 could be a potential intervention target for slowing tumor progression.<\/jats:p>","DOI":"10.1111\/cas.15598","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T07:55:05Z","timestamp":1664351705000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<scp>CXC chemokine ligand\u201010<\/scp> promotes the accumulation of monocyte\u2010like myeloid\u2010derived suppressor cells by activating p38 <scp>MAPK<\/scp> signaling under tumor conditions"],"prefix":"10.1111","volume":"114","author":[{"given":"Yingying","family":"Sun","sequence":"first","affiliation":[{"name":"The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, School of Life Science Northeast Normal 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