{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:06:19Z","timestamp":1778310379167,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K18031"],"award-info":[{"award-number":["JP19K18031"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","award":["the Grant for Joint Research Project of The Instit"],"award-info":[{"award-number":["the Grant for Joint Research Project of The Instit"]}],"id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemotherapy\u2010induced alopecia is frequently induced by various regimens of chemotherapy and has a significant impact on mental health and quality of life. However, the effect of available current treatment for chemotherapy\u2010induced alopecia is not sufficient. This study aimed to clarify the therapeutic effects and mechanism of skin cooling and the antioxidant \u03b1\u2010lipoic acid derivative on chemotherapy\u2010induced alopecia. We developed a chemotherapy\u2010induced alopecia model of cyclophosphamide (120\u2009\u03bcg\/g) using Institute of Cancer Research mice. We used cooling therapy and \u03b1\u2010lipoic acid derivative application as the treatments. We compared the alopecia score, hair bulb diameter, insulin\u2010like growth factor\u20101 level, vascular permeability, and apoptosis between the control and treatment groups. The alopecia score significantly improved in each treatment group compared with that in the cyclophosphamide group. Hair bulb diameter significantly improved in the cyclophosphamide\u2009+\u2009cooling group compared with that in the cyclophosphamide group. The insulin\u2010like growth factor\u20101 level and vascular permeability level was significantly retained and suppressed, respectively, in each treatment group compared with that in the cyclophosphamide group. The number of apoptotic cells in the vascular endothelium significantly decreased in the cyclophosphamide + \u03b1\u2010lipoic acid derivative group compared with that in the cyclophosphamide group. In conclusion, cooling therapy and \u03b1\u2010lipoic acid derivative facilitated recovery from chemotherapy\u2010induced alopecia caused by cyclophosphamide through decreasing vascular permeability.<\/jats:p>","DOI":"10.1111\/cas.15639","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T08:53:09Z","timestamp":1667811189000},"page":"1007-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of cooling therapy and \u03b1\u2010lipoic acid derivative against chemotherapy\u2010induced alopecia in an animal model"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-5270","authenticated-orcid":false,"given":"Takayuki","family":"Aiba","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical Research and Development for Cancer and Hair [Aderans] Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Etoh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu Japan"},{"name":"Faculty of Engineering University of Toyama  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-3688","authenticated-orcid":false,"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu Japan"},{"name":"Department of Advanced Medical Research and Development for Cancer and Hair [Aderans] Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3268"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0562-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.055"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.001"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"170","article-title":"Scalp hypothermia in the prevention of doxorubicin\u2010induced hair loss","volume":"11","author":"Giaccone G","year":"1988","journal-title":"Cancer Nurs"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3133"},{"key":"e_1_2_12_8_1","first-page":"2021","volume-title":"Clinical Guideline for Appearance Care in Cancer Treatment","author":"Cancer JAoSCi","year":"2021"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20939"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4983-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2019.12.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06773.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4481-z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208118"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05164-5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14396"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23787.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2003.09.009"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"719","article-title":"Chemotherapy\u2010induced alopecia in mice. 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