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We here investigated the oncolytic activity of CVA11 with human MPM cell lines. CVA11 infection was cytotoxic in all six MPM cell lines examined and showed no or minimal cytotoxicity toward normal human normal cell lines. MPM cells with a higher surface level of intercellular adhesion molecule\u20101 (ICAM\u20101) expression tended to be more susceptible to CVA11\u2010induced cytotoxicity, and a neutralizing antibody to ICAM\u20101 attenuated such cytotoxicity. CVA11 infection activated signaling by Akt and extracellular signal\u2010regulated kinase (ERK) pathways, and inhibitors of such signaling also abrogated CVA11\u2010mediated cytotoxicity. Furthermore, CVA11 infection\u2010triggered multiple modes of tumor cell death including apoptosis, pyroptosis, and necroptosis, and such death was accompanied by the release or exposure of the proinflammatory cytokine interleukin\u20101\u03b2 and damage\u2010associated molecular patterns such as calreticulin, high\u2010mobility group box\u20101, annexin A1, and heat shock protein 70, which are hallmarks of immunogenic cell death. Notably, in vivo treatment of human MPM xenografts with intratumoral CVA11 injection resulted in significant suppression of tumor growth in SCID mice, and all mice infected with CVA11 showed no significant change in body weight. Our findings collectively suggest that the oncolytic activity of CVA11 for MPM is dependent on ICAM\u20101 as a virus receptor, as well as on Akt and ERK signaling, and that oncolytic virotherapy with CVA11 is a promising treatment modality with immunostimulatory activity for human MPM.<\/jats:p>","DOI":"10.1111\/cas.15645","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T08:50:32Z","timestamp":1668243032000},"page":"1095-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunostimulatory oncolytic activity of coxsackievirus <scp>A11<\/scp> in human malignant pleural mesothelioma"],"prefix":"10.1111","volume":"114","author":[{"given":"Koji","family":"Okamura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Graduate School of Medical Sciences Kyushu University  Fukuoka 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