{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:16:53Z","timestamp":1782893813888,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Wnt\/\u03b2\u2010catenin signaling pathway plays a key role in development and carcinogenesis. Although some target genes of this signaling have been identified in various tissues and neoplasms, the comprehensive understanding of the target genes and their roles in the development of human cancer, including hepatoma and colorectal cancer remain to be fully elucidated. In this study, we searched for genes regulated by the Wnt signaling in liver cancer using HuH\u20107 hepatoma cells. A comparison of the expression profiles between cells expressing an active form of mutant \u03b2\u2010catenin and cells expressing enhanced green fluorescent protein (EGFP) identified seven genes upregulated by the mutant \u03b2\u2010catenin gene (<jats:italic>CTNNB1<\/jats:italic>). Among the seven genes, we focused in this study on <jats:italic>ODAM<\/jats:italic>, odontogenic,\u00a0ameloblast associated, as a novel target gene. Interestingly, its expression was frequently upregulated in hepatocellular carcinoma, colorectal adenocarcinoma, and hepatoblastoma. We additionally identified a distant enhancer region that was associated with the \u03b2\u2010catenin\/TCF7L2 complex. Further analyses revealed that <jats:italic>ODAM<\/jats:italic> plays an important role in the regulation of the cell cycle, DNA synthesis, and cell proliferation. These data may be useful for clarification of the main molecular mechanism(s) underlying these cancers.<\/jats:p>","DOI":"10.1111\/cas.15657","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T09:53:30Z","timestamp":1668592410000},"page":"948-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of odontogenic ameloblast associated as a novel target gene of the Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-4369","authenticated-orcid":false,"given":"Kiyoshi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Division of Clinical Genome Research, The Institute of Medical Science The University of Tokyo  Tokyo 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