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Here, we found that METTL3 was significantly upregulated in cervical cancer tissue, and its upregulation was associated with a poor prognosis in cervical cancer patients. Knockdown of METTL3 significantly reduced cervical cancer cell migration and invasion. Conversely, METTL3 overexpression markedly promoted cervical cancer cell metastasis in vitro and in vivo. Furthermore, METTL3 mediated the m6A modification of cathepsin L (<jats:italic>CTSL<\/jats:italic>) mRNA at the 5\u2032\u2010UTR, and the m6A reader protein insulin\u2010like growth factor 2 mRNA\u2010binding protein 2 (IGF2BP2) bound to the m6A sites and enhanced <jats:italic>CTSL<\/jats:italic> mRNA stability. Our results indicated that METTL3 enhanced <jats:italic>CTSL<\/jats:italic> mRNA stability through an m6A\u2010IGF2BP2\u2010dependent mechanism, thereby promoting cervical cancer cell metastasis. These findings provide insights into a novel m6A modification pattern involved in cervical cancer development.<\/jats:p>","DOI":"10.1111\/cas.15658","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T09:49:18Z","timestamp":1668592158000},"page":"837-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Methyltransferase\u2010like 3 promotes cervical cancer metastasis by enhancing cathepsin L <scp>mRNA<\/scp> stability in an N6\u2010methyladenosine\u2010dependent manner"],"prefix":"10.1111","volume":"114","author":[{"given":"Pingping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou 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