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This type of lymphoma may have specific expression profiles of chemokines involved in the pathogenesis of DLBCL\u2010CI. EBV\u2010positive pyothorax\u2010associated lymphoma (PAL) is a prototype of DLBCL\u2010CI and represents a valuable model for the study of this disease category. Using a panel of PAL cell lines, we found that PAL cells expressed and secreted C\u2013X\u2013C motif chemokine ligands 9 and 10 (CXCL9 and CXCL10), the ligands of CXCR3, in contrast to EBV\u2010negative DLBCL cell lines, which did not. Culture supernatants from PAL cell lines attracted CXCR3\u2010expressing CD4<jats:sup>+<\/jats:sup> T cells, CD8<jats:sup>+<\/jats:sup> T cells, and CD56<jats:sup>+<\/jats:sup> natural killer cells from human peripheral blood mononuclear cells. PAL cells injected into mice also attracted CXCR3\u2010positive cytotoxic lymphocytes that expressed interferon\u2010\u03b3. The expression of CXCL9 and CXCL10 was detected in PAL tumor biopsy samples from patients, and CXCR3\u2010positive lymphocytes were abundant in the tissue samples. Collectively, these findings suggest that CXCL9 and CXCL10 are produced by PAL cells and can elicit cytotoxic responses via CXCR3. This chemokine system is also likely to contribute to tissue necrosis, which is a signature histological feature of DLBCL\u2010CI. Further studies are warranted to determine whether the CXCL9\u2013CXCL10\/CXCR3 axis exerts antitumor effects in DLBCL\u2010CI.<\/jats:p>","DOI":"10.1111\/cas.15782","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T02:13:44Z","timestamp":1678500824000},"page":"2622-2633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>EBV<\/scp>\u2010positive pyothorax\u2010associated lymphoma expresses <scp>CXCL9<\/scp> and <scp>CXCL10<\/scp> chemokines that attract cytotoxic lymphocytes via <scp>CXCR3<\/scp>"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-3040","authenticated-orcid":false,"given":"Tomonori","family":"Higuchi","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infection, Kochi Medical School Kochi University  Nankoku 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