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It has been reported that AKR7A3 is downregulated in pancreatic cancer (PC). However, the mechanism underlying the effects of AKR7A3 in PC remains largely unclarified. Here, we explored the biological function, molecular mechanism and clinical relevance of AKR7A3 in pancreatic ductal adenocarcinoma (PDAC). AKR7A3 expression was downregulated in PDAC compared with adjacent normal tissues, and the lower AKR7A3 expression was related to poor prognosis. In addition, our results demonstrated that AKR7A3 could be a potential diagnostic marker for PDAC, especially in the early stages. Knockdown of AKR7A3 promoted PDAC progression and chemoresistance, while inhibiting autophagy flux. Mechanistically, AKR7A3 affected the metastasis, autophagy, and chemoresistance of PDAC by regulating PHGDH. Overall, the present study suggests that AKR7A3 inhibits PDAC progression by regulating PHGDH\u2010induced autophagy. In addition, AKR7A3 inhibits chemoresistance via regulating PHGDH and may serve as a new therapeutic target for PDAC.<\/jats:p>","DOI":"10.1111\/cas.15798","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T12:24:41Z","timestamp":1679574281000},"page":"3101-3113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>AKR7A3<\/scp> modulates the metastasis of pancreatic ductal adenocarcinoma through regulating <scp>PHGDH<\/scp>\u2010suppressed autophagy"],"prefix":"10.1111","volume":"114","author":[{"given":"Lei","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Oncology Tangdu Hospital Air Force Medical University  Xi'an 710038 Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oncology Tangdu Hospital Air Force Medical University  Xi'an 710038 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