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It is also shown that ANP32B acts as a tumor\u2010promoting gene in some kinds of cancer such as breast cancer and chronic myelogenous leukemia. Herein, we observe that ANP32B is lowly expressed in B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) patients, which correlates with poor prognosis. Furthermore, we utilized the N\u2010myc or BCR\u2010ABL<jats:sup>p190<\/jats:sup>\u2010induced B\u2010ALL mouse model to investigate the role of ANP32B in B\u2010ALL development. Intriguingly, conditional deletion of <jats:italic>Anp32b<\/jats:italic> in hematopoietic cells significantly promotes leukemogenesis in two B\u2010ALL mouse models. Mechanistically, ANP32B interacts with purine rich box\u20101 (PU.1) and enhances the transcriptional activity of PU.1 in B\u2010ALL cells. Overexpression of PU.1 dramatically suppresses B\u2010ALL progression, and highly expressed PU.1 significantly reverses the accelerated leukemogenesis in <jats:italic>Anp32b\u2010<\/jats:italic>deficient mice. Collectively, our findings identify ANP32B as a suppressor gene and provide novel insight into B\u2010ALL pathogenesis.<\/jats:p>","DOI":"10.1111\/cas.15822","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:20:15Z","timestamp":1683159615000},"page":"2882-2894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>ANP32B<\/scp> suppresses B\u2010cell acute lymphoblastic leukemia through activation of <scp>PU<\/scp>.1 in mice"],"prefix":"10.1111","volume":"114","author":[{"given":"Qian","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui\u2010Jin Hospital Shanghai Jiao\u2010Tong University School of Medicine (SJTU\u2010SM)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Ran","family":"Liu","sequence":"additional","affiliation":[{"name":"Key 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