{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:24:39Z","timestamp":1774279479625,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reports on the therapeutic efficacy and safety of carbon\u2010ion radiotherapy (C\u2010ion RT) for oligometastatic liver disease are limited, with insufficient evidence. This study aimed to evaluate the clinical outcomes of C\u2010ion RT for oligometastatic liver disease at all Japanese facilities using the nationwide cohort data. We reviewed the medical records to obtain the nationwide cohort registry data on C\u2010ion RT between May 2016 and June 2020. Patients (1) with oligometastatic liver disease as confirmed by histological or diagnostic imaging, (2) with \u22643 synchronous liver metastases at the time of treatment, (3) without active extrahepatic disease, and (4) who received C\u2010ion RT for all metastatic regions with curative intent were included in this study. C\u2010ion RT was performed with 58.0\u201376.0\u2009Gy (relative biological effectiveness [RBE]) in 1\u201320 fractions. In total, 102 patients (121 tumors) were enrolled in this study. The median follow\u2010up duration for all patients was 19.0\u2009months. The median tumor size was 27\u2009mm. The 1\u2010year\/2\u2010year overall survival, local control, and progression\u2010free survival rates were 85.1%\/72.8%, 90.5%\/78.0%, and 48.3%\/27.1%, respectively. No patient developed grade 3 or higher acute or late toxicity. C\u2010ion RT is a safe and effective treatment for oligometastatic liver disease and may be beneficial as a local treatment option in multidisciplinary treatment.<\/jats:p>","DOI":"10.1111\/cas.15871","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T01:42:07Z","timestamp":1688175727000},"page":"3679-3686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carbon\u2010ion radiotherapy for oligometastatic liver disease: A national multicentric study by the Japan Carbon\u2010Ion Radiation Oncology Study Group (J\u2010CROS)"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-4113","authenticated-orcid":false,"given":"Shintaro","family":"Shiba","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"},{"name":"Department of Radiation Oncology Shonan Kamakura General Hospital  Kamakura Japan"},{"name":"Department of Radiation Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Wakatsuki","sequence":"additional","affiliation":[{"name":"QST Hospital National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Toyama","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA\u2010HIMAT Foundation  Tosu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Terashima","sequence":"additional","affiliation":[{"name":"Department of Radiology Hyogo Ion Beam Medical Center  Tatsuno Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Osaka Heavy Ion Therapy Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"},{"name":"Department of Radiology Gunma Prefectural Cancer Center  Ota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-2546","authenticated-orcid":false,"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"QST Hospital National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.1.8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-112"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-018-1185-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-619"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1833-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00818"},{"key":"e_1_2_11_9_1","unstructured":"ASTRO model policies stereotactic body radiation therapy.ASTROSBRTModelPolicypdf. 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