{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:45:55Z","timestamp":1787737555199,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer in children, adolescents, and young adults (AYAs) although rare, is the leading disease\u2010specific cause of death in Japan. This study aims to investigate cancer incidence and type of treatment hospital among children and AYAs in Japan. Cancer incidence data (2016\u20132018) for those aged 0\u201339\u2009years were obtained from the Japanese population\u2010based National Cancer Registry. Cancer types were classified according to the 2017 update of the International Classification of Childhood Cancer (Third Edition), and AYA Site Recode 2020 Revision. Cases were also categorized into three groups: those treated at core hospitals for pediatric cancer treatment (pediatric cancer hospitals [PCHs]), those treated at designated cancer care hospitals, and those treated at nondesignated hospitals. The age\u2010standardized incidence rate was 166.6 (per million\u2010person years) for children (age 0\u201314\u2009years) and 579.0 for AYAs (age 15\u201339\u2009years) (including all cancers and benign or uncertain\u2010behavior central nervous system [CNS] tumors). The type of cancer varied with age: hematological malignancies, blastomas, and CNS tumors were common in children under 10\u2009years, malignant bone tumors and soft tissue sarcomas were relatively common in teenagers, and in young adults over 20\u2009years, carcinomas in thyroid, testis, gastrointestinal, female cervix, and breast were common. The proportion of cases treated at PCHs ranged from 20% to 30% for children, 10% or less for AYAs, and differed according to age group and cancer type. Based on this information, the optimal system of cancer care should be discussed.<\/jats:p>","DOI":"10.1111\/cas.15892","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T22:51:16Z","timestamp":1688683876000},"page":"3770-3782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cancer incidence and type of treatment hospital among children, adolescents, and young adults in Japan, 2016\u20132018"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-8637","authenticated-orcid":false,"given":"Kayo","family":"Nakata","sequence":"first","affiliation":[{"name":"Cancer Control Center Osaka International Cancer Institute  Osaka Japan"},{"name":"National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-1233","authenticated-orcid":false,"given":"Tomohiro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Nursing University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-0865","authenticated-orcid":false,"given":"Hiromi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Radiation Effects Research Foundation  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Tokyo Cancer Registry, Bureau of Social Welfare and Public Health Tokyo Metropolitan Government  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-4971","authenticated-orcid":false,"given":"Isao","family":"Miyashiro","sequence":"additional","affiliation":[{"name":"Cancer Control Center Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimikazu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-5482","authenticated-orcid":false,"given":"Akihiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Surgery, Surgical Oncology National Center for Child Health and Development  Tokyo Japan"},{"name":"Division of Pediatric Surgical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-6520","authenticated-orcid":false,"given":"Junko","family":"Takita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8687-1269","authenticated-orcid":false,"given":"Kota","family":"Katanoda","sequence":"additional","affiliation":[{"name":"National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_11_3_1","unstructured":"Ministry of Health Labour and Welfare.Vital Statistics of Japan.2022. 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