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The downstream MAPK\/AKT pathway was suppressed at the protein level following pazopanib treatment. The fusion genes were classified into four subgroups by cluster analysis of the gene expression data and gene set enrichment analysis. In summary, the oncogenicity and drug sensitivity of 59 fusion genes were simultaneously evaluated using a high\u2010throughput strategy. Pazopanib was selected as a candidate drug for sarcomas harboring the <jats:italic>COL1A1\u2010PDGFB<\/jats:italic> fusion gene. 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