{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:50:59Z","timestamp":1763621459896,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18lm0203004"],"award-info":[{"award-number":["JP18lm0203004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) is one of the most frequently occurring cancers in children and is associated with a poor prognosis. Here, we performed large\u2010scale screening of natural compound libraries to identify potential drugs against T\u2010ALL. We identified three low\u2010molecular\u2010weight compounds (auxarconjugatin\u2010B, rumbrin, and lavendamycin) that inhibited the proliferation of the T\u2010ALL cell line CCRF\u2010CEM, but not that of the B lymphoma cell line Raji in a low concentration range. Among them, auxarconjugatin\u2010B and rumbrin commonly contained a polyenyl 3\u2010chloropyrrol in their chemical structure, therefore we chose auxarconjugatin\u2010B for further analyses. Auxarconjugatin\u2010B suppressed the in vitro growth of five human T\u2010ALL cell lines and two T\u2010ALL patient\u2010derived cells, but not that of adult T\u2010cell leukemia patient\u2010derived cells. Cultured normal T cells were several\u2010fold resistant to auxarconjugatin\u2010B. Auxarconjugatin\u2010B and its synthetic analogue Ra#37 depolarized the mitochondrial membrane potential of CCRF\u2010CEM cells within 3\u2009h of treatment. These compounds are promising seeds for developing novel anti\u2010T\u2010ALL drugs.<\/jats:p>","DOI":"10.1111\/cas.15918","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:39:28Z","timestamp":1690799968000},"page":"4032-4040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of compounds that preferentially suppress the growth of T\u2010cell acute lymphoblastic leukemia\u2010derived cells"],"prefix":"10.1111","volume":"114","author":[{"given":"Kazuya","family":"Miyashita","sequence":"first","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Division of Cellular Therapy The Institute of Medical Science, The University of Tokyo  Minato\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yagi","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritaka","family":"Kagaya","sequence":"additional","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology  Koto\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Takechi","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Science, Department of Biological Science Tokyo Metropolitan University  Hachioji\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Nakata","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Kanda","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideko","family":"Nuriya","sequence":"additional","affiliation":[{"name":"Core Technology and Research Center Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tanegashima","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Hoyano","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Science, Department of Biological Science Tokyo Metropolitan University  Hachioji\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiya","family":"Seki","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Chofu Japan"},{"name":"Center for Neuroscience and Biomedical Engineering The University of Electro\u2010Communications  Chofu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Hachiro","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Chofu Japan"},{"name":"Center for Neuroscience and Biomedical Engineering The University of Electro\u2010Communications  Chofu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Chofu Japan"},{"name":"Center for Neuroscience and Biomedical Engineering The University of Electro\u2010Communications  Chofu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kitada","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Chofu Japan"},{"name":"Center for Neuroscience and Biomedical Engineering The University of Electro\u2010Communications  Chofu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-972X","authenticated-orcid":false,"given":"Takashi","family":"Toya","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-0021","authenticated-orcid":false,"given":"Yuho","family":"Najima","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-1826","authenticated-orcid":false,"given":"Susumu","family":"Goyama","sequence":"additional","affiliation":[{"name":"Division of Cellular Therapy The Institute of Medical Science, The University of Tokyo  Minato\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shojiro A.","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro\u2010Communications  Chofu Japan"},{"name":"Center for Neuroscience and Biomedical Engineering The University of Electro\u2010Communications  Chofu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Cellular Therapy The Institute of Medical Science, The University of Tokyo  Minato\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Doki","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Shin\u2010ya","sequence":"additional","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology  Koto\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-0720","authenticated-orcid":false,"given":"Takahiko","family":"Hara","sequence":"additional","affiliation":[{"name":"Stem Cell Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Japan"},{"name":"Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"},{"name":"Graduate School of Science, Department of Biological Science Tokyo Metropolitan University  Hachioji\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-706465"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00273"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60457-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-056754"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1465"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0093"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00843"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.135"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00237-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.888"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.884"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.2.5.441"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127837"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100619x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067603"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:22:01Z","timestamp":1696533721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.15918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/cas.15918"],"URL":"https:\/\/doi.org\/10.1111\/cas.15918","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"type":"print","value":"1347-9032"},{"type":"electronic","value":"1349-7006"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"2023-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}