{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:51:02Z","timestamp":1779889862093,"version":"3.53.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802656"],"award-info":[{"award-number":["81802656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071754"],"award-info":[{"award-number":["82071754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072906"],"award-info":[{"award-number":["82072906"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271793"],"award-info":[{"award-number":["82271793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012238"],"award-info":[{"award-number":["2022A1515012238"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SYS\u20105010\u2010202308"],"award-info":[{"award-number":["SYS\u20105010\u2010202308"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported the results of a phase II trial of anti\u2010PD\u20101 antibody plus anti\u2010vascular endothelial growth factor receptor 2 inhibitors and eribulin in heavily pretreated advanced triple\u2010negative breast cancer with a favorable objective response rate (ORR) of 37.0% (NCT04303741). Here we report updated survival outcomes and serum metabolite changes of the study. Proton nuclear magnetic resonance spectroscopy was used to detect metabolite dynamics and explore biomarkers for response. We found that treatment\u2010sensitive patients had higher very low\u2010density lipoprotein\u2010related metabolite expression at baseline. A lipid proteomics model consisting of six metabolites predicted ORR and progression\u2010free survival at 6\u2009months with area under the receiver operating characteristic curves of 0.88 and 0.87, respectively. Serum asparagine and sarcosine concentrations were significantly higher after treatment in treatment\u2010resistant patients. In conclusion, we constructed a model consisting of six metabolites to identify patients who benefit more from the triplet treatment, and asparagine and sarcosine may be associated with treatment resistance.<\/jats:p>","DOI":"10.1111\/cas.15937","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T22:39:38Z","timestamp":1693262378000},"page":"3924-3934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of <scp><sup>1<\/sup>H\u2010NMR<\/scp> serum lipoproteins on immunotherapy response in advanced triple\u2010negative breast cancer patients"],"prefix":"10.1111","volume":"114","author":[{"given":"Zhenluan","family":"Tian","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunxian","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanghai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Clinical Multiomics  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Clinical Multiomics  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-831X","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0002"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1210-4"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32531-9"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30689-8"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000696"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-20-4726"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30569-0"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4224"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.8931"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4537-5"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910549"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0312-8"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.Mct-17-0386"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126908"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2031965"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.15_suppl.e12659"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092846"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0203-7"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01200-4"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13444"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-21-1179"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19694-w"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.25.6529"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-18-asocco"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02412"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00710-w"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01924-1"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.11.033"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12488"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.80"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-021-01310-4"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97327-y"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2013-0016"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.158518"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(18)30812-x"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06128-4"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11457"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25465"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07762"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.602416"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.09.002"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-022-00614-0"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.15937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:21:43Z","timestamp":1696533703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.15937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/cas.15937"],"URL":"https:\/\/doi.org\/10.1111\/cas.15937","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"2023-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}