{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:19:54Z","timestamp":1791285594333,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite numerous observational studies indicating an increased risk of cutaneous melanoma (CM) due to childhood sunburn, no studies have established a definitive cause\u2010and\u2010effect relationship. Therefore, our objective was to employ a Mendelian randomization (MR) design to explore a possible causal association between childhood sunburn and the risk of CM. To investigate the causal relationship between childhood sunburn and CM, we used large\u2010scale genetic summary\u2010level data from genome\u2010wide association studies (GWAS), including childhood sunburn (<jats:italic>n<\/jats:italic>\u2009=\u2009346,955) and CM (<jats:italic>n<\/jats:italic>\u2009=\u2009262,288), building upon previous observational studies. In the analysis, we mainly used the inverse\u2010variance weighted (IVW) method of the random effects model, supplemented by the weighted median method and MR\u2010Egger method. The results of the IVW method demonstrated that genetically predicted childhood sunburn was significantly associated with higher odds of CM, with an odds ratio (OR) of 2.418 (95%CI, 1.426\u20134.099; <jats:italic>p<\/jats:italic>\u2009=\u2009.001). The weighted median method and MR\u2010Egger regression also demonstrated directionally similar results (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Furthermore, both the funnel plot and the MR\u2010Egger intercepts showed the absence of directional pleiotropy between childhood sunburn and CM. Our study offers potential evidence linking genetically predicted childhood sunburn with CM, underscoring the need for individuals with a history of childhood sunburn to be extra vigilant regarding the occurrence of CM.<\/jats:p>","DOI":"10.1111\/cas.15974","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T06:08:20Z","timestamp":1695794900000},"page":"4706-4716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through Mendelian randomization"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4867-9146","authenticated-orcid":false,"given":"Shengdong","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Plastic surgery Longyan First Affiliated Hospital of Fujian Medical University  Longyan 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