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We tried to evaluate the clinical outcomes of these patients. We collected data from 1036 patients with multiple myeloma and enrolled 509 cases with COVID\u201019. We divided enrolled patients into daratumumab or nondaratumumab cohorts based on whether they had received daratumumab\u2010based treatment within 6\u2009months of COVID\u201019 infection. We applied a propensity score matching method to reduce the bias of baseline characteristics, and then compared the incidence of adverse outcomes between these two cohorts. A total of 117 patients were enrolled in the daratumumab cohort, and 392 patients in the nondaratumumab cohort. After propensity score matching, 204 patients were matched. The proportions of patients who developed COVID\u201019 pneumonia (59.8% vs. 34.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), were hospitalized (33.3% vs. 11.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and developed severe disease (23.5% vs. 6.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) were higher in the matched daratumumab cohort. By multivariate analysis, daratumumab exposure was an independent risk factor for severe disease. An ECOG performance status\u2009&gt;2 and history of chronic kidney disease were independent risk factors for COVID\u201019\u2010related mortality among patients who received daratumumab\u2010based therapy. This study suggested that multiple myeloma patients exposed to daratumumab were at a higher risk of adverse outcomes from COVID\u201019.<\/jats:p>","DOI":"10.1111\/cas.16001","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:28:46Z","timestamp":1698366526000},"page":"237-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of <scp>COVID<\/scp>\u201019 in multiple myeloma patients treated with daratumumab"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-7239","authenticated-orcid":false,"given":"Dian","family":"Jin","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Hematology Ningbo Medical Treatment Center Li Huili Hospital  Ningbo 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Immunity Therapy  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Han","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University Medical Center  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Hematology Ningbo Medical Treatment Center Li Huili Hospital  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Hematology Ningbo Medical Treatment Center Li Huili Hospital  Ningbo 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