{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:25:12Z","timestamp":1787635512926,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["2020060"],"award-info":[{"award-number":["2020060"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["202103021224431"],"award-info":[{"award-number":["202103021224431"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20210302123340"],"award-info":[{"award-number":["20210302123340"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circulating miRNAs (cirmiRNAs) can be packaged into the exosomes, participating in intercellular communication, which affects the malignant progression and therapy resistance of triple\u2010negative breast cancer (TNBC). Currently, immune checkpoint inhibitors that regulate T\u2010cell function, especially antibodies against programmed cell death 1 (PD\u20101) or its ligand PD\u2010L1, are emerging as new promising therapy for TNBC patients. However, only very limited patients showed complete or partial response to anti\u2010PD\u20101 treatment. Dysfunction of CD8<jats:sup>+<\/jats:sup> T cells is one of the key reasons for the immune escape of TNBC. The regulation of exosome\u2010derived cirmiRNAs on CD8<jats:sup>+<\/jats:sup> T\u00a0cells in TNBC deserves more investigation. Here, the cirmiR\u201020a\u20105p level was significantly upregulated in the plasma of TNBC patients and culture supernatant of TNBC cells. High abundance of cirmiR\u201020a\u20105p was correlated with a worse prognosis of TNBC. cirmiR\u201020a\u20105p was secreted in the form of exosomes by TNBC cells. Exosomal cirmiR\u201020a\u20105p was internalized into CD8<jats:sup>+<\/jats:sup> T cells and resulted into the dysfunction of CD8<jats:sup>+<\/jats:sup> T. A mechanism study uncovered that cirmiR\u201020a\u20105p targeted the nuclear protein ataxia\u2010telangiectasia (NPAT) and decreased NPAT expression in CD8<jats:sup>+<\/jats:sup> T cells. An in\u00a0vivo xenograft mouse model showed that cirmiR\u201020a\u20105p conferred TNBC to anti\u2010PD\u20101 treatment resistance. Collectively, these findings indicated that cirmiR\u201020a\u20105p released by TNBC cells via exosome promotes cancer cell growth and leads to the immunosuppression by inducing CD8<jats:sup>+<\/jats:sup> T cell dysfunction. This study suggests that targeting cirmiR\u201020a\u20105p might be a novel strategy for overcoming the resistance of TNBC to anti\u2010PD\u20101 immunotherapy.<\/jats:p>","DOI":"10.1111\/cas.16036","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T02:29:11Z","timestamp":1703212151000},"page":"347-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cancer cell\u2010derived exosomal <scp>miR<\/scp>\u201020a\u20105p inhibits <scp>CD8<\/scp><sup>+<\/sup> T\u2010cell function and confers <scp>anti\u2010<\/scp>programmed cell death 1 therapy resistance in triple\u2010negative breast cancer"],"prefix":"10.1111","volume":"115","author":[{"given":"Weina","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-0892","authenticated-orcid":false,"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan 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