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The specific effects of RGS1 in the dynamic progression from chronic gastritis to gastric cancer have not been reported, and the role of tumor\u2010associated macrophages (TAMs) is also unclear. In the present study, <jats:italic>RGS1<\/jats:italic> was identified as an upregulated gene in different pathological stages ranging from chronic gastritis to gastric cancer by using Gene Expression Omnibus (GEO) screening together with pancancer analysis of The Cancer Genome Atlas and clinical prognostic analysis. The results indicated that RGS1 is highly expressed in gastric cancer and has potential prognostic value. We confirmed through in\u00a0vivo experiments that RGS1 inhibited the proliferation of gastric cancer cells and promoted apoptosis, which was further corroborated by in\u00a0vitro experiments. Additionally, RGS1 influenced cell migration and invasion. In our subsequent investigation of RGS1, we discovered its role in the immune response. Through analyses of single\u2010cell and GEO database data, we confirmed its involvement in immune cell regulation, specifically TAM activation. Subsequently, we conducted in\u00a0vivo and in\u00a0vitro experiments to confirm the involvement of RGS1 in polarizing M1 macrophages while indirectly regulating M2 macrophages through tumor cells. In conclusion, RGS1 could be a potential target for the transformation of chronic gastritis into gastric cancer and has a measurable impact on TAMs, which warrants further in\u2010depth research.<\/jats:p>","DOI":"10.1111\/cas.16083","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T08:09:21Z","timestamp":1706602161000},"page":"1085-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>Regulator of G<\/scp> protein signaling 1 is a potential target in gastric cancer and impacts tumor\u2010associated macrophages"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-8028","authenticated-orcid":false,"given":"Mengting","family":"Wu","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Key Labortory of Blood\u2010Stasis\u2010Toxin Syndrome of Zhejiang 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