{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:00:06Z","timestamp":1783116006244,"version":"3.54.6"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer transmission may rarely occur between individuals. Besides through allogenic transplantation, cancer transmission via the hemochorial placenta, which is permissive for cell traffic, has been described in a few reports. Three etiologies of transplacental cancer transmission include (1) maternofetal transmission of maternal cancer cells, (2) transmission of gestational choriocarcinoma to the fetus, and (3) transfer of preleukemic cells from one monozygotic twin to the other. Additionally, we recently reported two pediatric cases of lung tumors in which the lung\u2010only distribution of tumors and genomic profiling of both the child's and mother's tumor samples suggested the airway\/transbronchial transmission of maternal cervical cancer cells to the child by aspiration at birth. The immune system coordinates the hemostatic balance between effector and regulatory immunity, especially during fetal development. The immunoregulatory properties are shared in both physiological pregnancy\u2010related and pathological cancer\u2010related conditions. Mechanistically, the survival and colonization of transmitted cancer cells within a child are likely attributed to a combination of the child's immune tolerance and the cancer's immune escape. In this review, we summarize the current understanding of gestational\/perinatal cancer transmission and discuss the possible mechanism\u2010based immunotherapy for this rare form of pediatric cancer.<\/jats:p>","DOI":"10.1111\/cas.16102","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T05:06:35Z","timestamp":1708319195000},"page":"1039-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>Cross\u2010individual<\/scp> cancer transmission to children during the gestational and perinatal periods"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6501-7814","authenticated-orcid":false,"given":"Ayumu","family":"Arakawa","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-706X","authenticated-orcid":false,"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitose","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25858"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00775-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPJUQ9DNR1GHP"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eoy011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030391"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195810092591507"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900301)65:5<1146::AID-CNCR2820650519>3.0.CO;2-J"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907083410204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.12.036"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904658106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-327627"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1949.tb07122.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:2<299::AID-CNCR2820030211>3.0.CO;2-#"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196508)18:8<1048::AID-CNCR2820180817>3.0.CO;2-V"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.57.6.978"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199808000-00015"},{"key":"e_1_2_11_18_1","first-page":"191","article-title":"Transplacental transmission of metastatic melanoma to the posterior fossa","volume":"103","author":"Trumble ER","year":"2005","journal-title":"J Neurosurg"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3181b6a546"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32833faf6a"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200205093461917"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/pdp.21.1.57.69"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850410005660"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1361-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041934"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318212ecb3"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-018-1362-9"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0015-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3817"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01756-1"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/363358a0"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.322"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.177"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00537-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282dc94e5"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0460-5"},{"key":"e_1_2_11_37_1","first-page":"155","article-title":"Advances in the epidemiology of gestational trophoblastic disease","volume":"39","author":"Palmer JR","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60280-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4274\/jtgga.galenos.2023.2023-5-2"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gynor.2014.04.001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.03.026"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2636"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32894-5"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00803"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533972"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70504-7"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.41.030179.002123"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13969"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0811036"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32792391051.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.4.1445"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00588"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196509"},{"issue":"325","key":"e_1_2_11_54_1","first-page":"e321","article-title":"Maternal microchimerism in human fetal tissues","volume":"198","author":"Jonsson AM","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.38"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00266"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508054"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25480"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.16102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T04:18:29Z","timestamp":1712809109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.16102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,18]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/cas.16102"],"URL":"https:\/\/doi.org\/10.1111\/cas.16102","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,18]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}