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In the present study, we found that platelets stimulated by BLCA cell lines could promote M2 macrophage polarization, and platelets were significantly associated with the infiltration of M2 macrophages in BLCA samples. Through the bioinformatic analyses,\n                    <jats:italic>A2M<\/jats:italic>\n                    ,\n                    <jats:italic>TGFB3<\/jats:italic>\n                    , and\n                    <jats:italic>MYLK<\/jats:italic>\n                    , which were associated with platelets and M2 macrophages, were identified and verified in\u00a0vitro and then included in the predictive model. A platelet and M2 macrophage\u2010related gene signature was constructed to evaluate the prognosis and immunotherapeutic sensitivity, helping to guide personalized treatment and to disclose the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/cas.16113","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:30:11Z","timestamp":1709220611000},"page":"1417-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Development and experimental validation of an M2 macrophage and platelet\u2010associated gene signature to predict prognosis and immunotherapy sensitivity in bladder cancer"],"prefix":"10.1111","volume":"115","author":[{"given":"Bahaerguli","family":"Muhuitijiang","sequence":"first","affiliation":[{"name":"Department of Urology, Nanfang Hospital Southern Medical University  Guangzhou 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